Clinical trial of Reduning injection combined with cefoperazone sodium and sulbactam sodium injection in the treatment of pulmonary infection in patients with chronic obstructive pulmonary disease
10.13699/j.cnki.1001-6821.2017.15.002
- VernacularTitle:热毒宁注射液联合头孢哌酮钠舒巴坦钠注射剂治疗慢性阻塞性肺疾病合并肺部感染的临床研究
- Author:
Hui HUANG
1
;
Jiu-Jin ZHANG
;
Dong YAN
;
Chun-Xian PENG
Author Information
1. 玉林市第三人民医院呼吸内科
- Keywords:
Reduning injection;
cefoperazone sodium and sulbactam sodium injection;
chronic obstructive pulmonary disease;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(15):1391-1393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety profile of Reduning injection combined with cefoperazone sodium and sulbactam sodium injection in the treatment of pulmonary infection in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 68 patients with COPD were divided into control group (34 cases) and treatment group (34 cases).Both groups were given routine treatment.The control group was given moxifloxacin hydrochloride sodium chloride injection 250 mL,intravenous drip,qd;cefoperazone sodium and sulbactam sodium 1.0 g,intravenous drip,bid.The treatment group received Reduning injection 20 mL,intravenous drip,qd.Both groups were treated for 10 days.The clinical efficacy and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates of the treatment group and the control group were respectively 94.12％ (32/34 cases),70.59％ (24/32 cases),the difference was statistically significant (P ＜ 0.05).The main adverse drug reactions of treatment group were headache,gastrointestinal reaction and rash,while those of the control group were headache,slight increase of liver enzymes,gastrointestinal reaction and rash,and the incidences of adverse drug reaction were 8.82％ (3/34 cases) and 14.71％ (5/34 cases) respectively,without statistically significant difference (P ＞0.05).Conclusion Reduning injection combined with cefoperazone sodium and sulbactam sodium injection in the treatment of COPD was effective with a favourable safety profile.
