Clinical analysis of adverse drug reactions to oxaliplatin combined fluorine-containing or taxanes-containing chemotherapy regimen
10.13699/j.cnki.1001-6821.2017.14.019
- VernacularTitle:奥沙利铂联合含氟或紫杉类化疗方案致药物不良反应的临床分析
- Author:
Meng-Di YU
1
;
Ming-Xia WANG
;
Zhang-Ying FENG
;
Li-Ying DU
Author Information
1. 河北医科大学第四医院药学部
- Keywords:
oxaliplatin;
adverse drug reaction;
chemotherapy regimen;
clinical rational administration
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(14):1354-1356,1384
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics and prevention strategy of adverse drug reactions (ADR) caused by oxaliplatin,so as to provide the basis for clinical rational use of drugs.Methods Seventy-eight cases reports of oxaliplatin ADR from January 2011 to December 2016 in our hospital were analyzed retrospectively.The clinical data of all cases including the first onset time,chemotherapy regimens and treatment cycle;cumulative dose of oxaliplatin,clinical manifestations,severity,strategies were collected and analyzed.Results In the patients with colorectal carcinoma,gastric carcinoma,cervical cancer,ovarian cancer and other malignancies who were administered chemotherapy containing oxaliplatin.Such as taxol and oxaliplatin (TP regimens),docetaxel and oxaliplatin (DP regimens),oxaliplatin + capecitabine (XELOX regimens),oxaliplatin + leucovorin + fluorouracil (mFOLFOX6 regimens),mFOLFOX6 plus bevacizumab regimens,oxaliplatin + leucovorin + fluorouracil (FOLFOX7 regimens),fluorouracil + oxaliplatin (FP regimens) and tegafur combined with oxaliplatin regimens for the treatment,all were fluorine-containing or taxanes-containing regimens.The maximum rate of ADR was 43.59％ of them treated with mFOLFOX6 regimens and 30.77％ of them treated with TP regimens (containing taxol and oxaliplatin),respectively.ADR induced by oxaliplatin usually occurred within 5-30 min (53.85％) after drug administration,generally within 24 h.Lesions of skin and its appendants (36.05％) and respiratory symptoms(27.21％) were the most common clinical manifestations.Conclusion Oxaliplatin combined fluorine-containing or taxanes-containing chemotherapy regimens prone to ADR.Colse attention must be paid to the patients who received oxaliplatin within 24 h,especially within 30 min.Patients who experienced a grade 3-4 ADR are urlikely to tolerate further therapy.
