Clinical trial of calcium dobesilate capsules combined with Danshen injection in the treatment of elderly patients with early diabetic retinopathy
10.13699/j.cnki.1001-6821.2017.14.005
- VernacularTitle:羟苯磺酸钙胶囊联合丹参注射液治疗老年2型糖尿病早期视网膜病变的临床疗效
- Author:
Li-Ping JIANG
1
;
Xiao-Lin ZHUANG
;
Qing-Feng WU
;
Qiang FU
;
Hong-Wei WANG
Author Information
1. 齐齐哈尔医学院第一附属医院眼科
- Keywords:
calcium dobesilate capsule;
Danshen injection;
type 2 early diabetic retinopathy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(14):1304-1306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of cal cium dobesilate capsules combined with Danshen injection in the treatment of elderly patients with early diabetic retinopathy.Methods A total of 58 elderly patients with early diabetic retinopathy were randomly divided into the control group and treatment group with 29 cases per group.Control group was given calcium dobesilate 0.5 g,tid,oral.Treatment group was treated with Danshen injection 20 mL,qd,intravenous drip,on the basis of the control group.Two groups were treated for 3 months.The clinical efficacy,serum levels of vascular endothelial growth factor (VEGF),insulin-like growth factor 1 (IGF-1) and high sensitive C-reactive protein (hs-CRP),adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 93.10％ (27/29 cases) and 72.41％ (21/29 cases) with statistically significant difference (P ＜0.05).After treatment,the main indexes in treatment and control groups were compared:VEGF were (82.32 ± 9.73),(105.24±10.05)pg · mL-1;IGF-1 were (89.66 ±8.79),(124.24 ±9.86)ng · mL-1;hs-CRP were (3.98 ± 0.52),(6.76 ± 0.83) mg · L-1,the differences were statistically significant (P ＜ 0.05).The adverse drug reactions in treatment group were based on facial flushing,nausea and vomiting,which in control group were nausea and vomiting,lack of appetite.The incidences of adverse drug reaction in treatment and control groups were 10.34％ and 6.90％ without significant difference (P ＞ 0.05).Conclusion Calcium dobesilate capsules combined with Danshen injection have a definitive clinical efficacy in the treatment of elderly patients with early diabetic retinopathy,which can significantly reduce the patients' serum levels of VEGF,IGF-1 and hs-CRP,without increasing the incidence of adverse drug reactions.
