Review of the research on 8-hydroxy-2 deoxyguanosine as a DNA oxidative damage marker

VernacularTitle:8-羟基脱氧鸟嘌呤作为DNA氧化损伤标志物的研究现状
Author: Chen YU ¹ ; Chao-Ran DONG ; Zhao-Hui ZHANG ; Qian LI ; Hui-Hui ZENG
Author Information

1. 北京大学天然药物及仿生药物国家重点实验室
Keywords: 8-hydroxy-2 deoxyguanine; DNA oxidative damage; tumor marker
From: The Chinese Journal of Clinical Pharmacology 2017;33(13):1267-1270
CountryChina
Language:Chinese
Abstract: 8-hydroxy-2 deoxyguanine (8-OHdG) as a biomarker of DNA oxidative damage,its expression level is closely related to the mutation of many oncogenes,and plays an important role in the occurrence,development and prognosis of cancer.8-OHdG can be an effective biomarker for the early screening,efficacy monitoring and prognosis evaluation of oxidative injury disease,and play an important role in clinical practice.This paper summarizes the previous clinical studies of 8-OHdG,which is intended to provide implications for its clinical application.