Experimental study of Coix lacryma-jobi (L.) leaf's water extract on the anti-fatigue and hypoxia tolerance function in mice
10.13699/j.cnki.1001-6821.2017.13.019
- VernacularTitle:薏苡叶水提液对小鼠抗疲劳与耐缺氧作用的实验研究
- Author:
Xun-Jie LIANG
1
;
Mian LU
;
Shu-Ting LI
;
Qiu-Meng WEI
;
Suo-Yi HUANG
;
Lu-Yao WANG
Author Information
1. 右江民族医学院临床医学院
- Keywords:
Coix lacryma-jobi (L.) leaf's water extract;
anti-fatigue;
hypoxia tolerance;
liver weight coefficient;
swimming
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(13):1237-1239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-fatigue and hypoxia tolerance function of Coix lacryma-jobi leaf's water extract in mice.Methods Normal male mice were averagely selected and divided into four groups by weight:control group,low dose,medium dose and high dose experimental groups.Coix lacryma-jobi leaf's water extract of different dose (1.5,4.5,7.5 g · kg-1) was given into the mice's stomach respectively in three experimental groups and distilled water was given in control group,every day for a continuous 14 days.Burdened swimming test and hypoxia tolerance test were conducted in mice to determine their swimming time and death time.Dissociating the mouse's liver,weighing the mouse's liver and calculating the liver weight coefficient.Results The burdened swimming time of the high dose group,medium dose group and low dose group were respectively 6.74,10.47,5.51 min.The hypoxia tolerance time of the high dose group,medium dose group and low dose group were respectively 46.48,54.96,54.90 min.The liver weight coefficient of the high dose group,medium dose group and low dose group were respectively 0.054,0.050,0.051.Compared with the control group,the burdened swimming time of the medium dose group was longer than that of the control group with significantly (P ＜ 0.05).The death time of the low dose group and the medium dose group were prolonged than that of the control group with significantly(all P ＜0.01).Weighing the mouse's liver and the liver weight coefficient in three experimental groups were all higher than the control group with significantly (all P ＜ 0.05).Conclusion Coix lacryma-jobi leaf's water extract had anti-fatigue and hypoxia tolerance function in mice.
