Study on value of serum tumor markers in predicting the survival of patients with hepatocellular carcinoma after operation
10.13699/j.cnki.1001-6821.2017.13.010
- VernacularTitle:血清肿瘤标记物变化对预测肝癌术后的生存价值的研究
- Author:
Hui-Zhen WU
1
;
Xiao LI
;
En-Hao WU
;
Kai-Shan TAO
Author Information
1. 滁州城市职业学院医学技术系
- Keywords:
soluble cell adhesion molecule-1;
protein induced by vitamin K absence or antagonist-Ⅱ;
hepatocellular carcinoma;
survival analysis
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(13):1201-1204
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between change of intercellular adhesion molecule-1 (ICAM-1) and protein induced by vitamin K absence or antagonist-Ⅱ (PIVKA-Ⅱ) after redical resection of hepatocellular carcinoma (HCC) and the prognosis of HCC.Methods Clinical data and prognosis of 137 HCC patients that accepted was retrospective analyzed.Levels of sICAM-1 and PIVKA-Ⅱ before and 1 month after surgery were examined.All the patients were divided into different groups according to the change of tumor makers after surgery.Accorded to the changes of serum PIVKA-Ⅱ and sICAM-1 levels were divided into N group(the level of biochemical index in normal value),D group (the level of biochemical index is higher than normal value preoperative) and UI group (biochemical index level is in normal value preoperative,but higher than normal value postoperative;or is higher than normal value preoperative,and still higher than normal value postoperative).Survival rates and clinical factors were analyzed between different groups.Results The Ⅲ-Ⅳ stage ratio of UI group,D group and N group were 49.1％,23.3％,20.0％,respectively.Child-Pugh stage B stage ratio in the three groups were 36.8％,18.3％,15.0％,respectively.Tumor diameter ＞ 5 cm ratio in the three groups were 56.1％,30.0％,5.0％,respectively.Recurrence ratio in the three groups were 36.8％,18.3％,15.0％,respectively.The sICMA-1 change and survival rate:the survival rates of 3,5 years disease free and 3,5 years overall in N group were 55％,35％;65％,45％.N group significantly high than UI group (26％,30％;12％,12％)and D group(33％,53％;13％,27％,all P ＜0.05).The PIVKA-Ⅱ change and survival rate:The survival rates of 3,5 years disease free and 3,5 years overall in N group were 47％,20％;57％,33％.N group significantly high than UI group(21％,9％;37％,12％,all P ＜ 0.05) Conclusion For the patients that accepted redical resection of HCC,combining analysis the change of sICAM-1 and PIVKA-Ⅱ may help to predict the prognosis of HCC.
