Research state on effect of traditional Chinese medicine injections on cytochrome P450 2C9 enzyme activity and the metabolism of cytochrome P450 2C9 substrate
10.13699/j.cnki.1001-6821.2017.12.025
- VernacularTitle:中药注射剂对细胞色素P450 2C9酶活性及细胞色素P450 2C9底物的药物代谢影响的研究现状
- Author:
Ze-Na CHANG
1
;
Chang-Qing YANG
Author Information
1. 中国药科大学基础医学与临床药学学院
- Keywords:
traditional Chinese medicine injections;
cytochrome P450 2C9 enzymes;
cytochrome P450 2C9 substrate;
pharmacokinetics;
drug interactions
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(12):1165-1168
- CountryChina
- Language:Chinese
-
Abstract:
There are hundreds of traditional Chinese medicine injections in clinic,but few studies on that effect on the activity of cytochrome P450 2C9 enzymes.Whether traditional Chinese medicine injection inhibit or induce the CYP2C9 enzyme activity,when utilizing medication through CYP2C9 metabolism,we should pay attention to the impact of traditional Chinese medicine injections for they may have metabolic drug interactions.In order to avoid the increase of adverse drug reactions and the decrease of drug efficacy,we should pay our attention to the study on the effect of traditional Chinese medicine injections on CYP2C9 activity.This article summarized and analyzed the effect of traditional Chinese medicine injections on the activity of CYP2C9 enzymes and understood the present situation of its research.
