Clinical trial of western medicine treatment combined with Xuefu Zhuyu decoction in the treatment elderly patients with refractory hypertension
10.13699/j.cnki.1001-6821.2017.12.023
- VernacularTitle:血府逐瘀汤联合西药治疗老年难治性高血压的临床研究
- Author:
Guan-Jun WANG
1
;
Lie-Min RUAN
;
Ni DAI
;
Yun-Xin JI
;
Ying CHAI
Author Information
1. 宁波市第一医院中西医结合科
- Keywords:
Xuefu Zhuyu decoction;
western medicine;
refractory hypertension
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(12):1158-1160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect of Xuefu Zhuyu decoction combined with western medicine on elderly patients with refractory hypertension.Methods A total of 120 elderly patients with refractory hypertension were randomly divided into treatment group (n =60) and control group (n =60).Control group was given propranolol 5-10 mg orally,tid or qid;captopril 12.5 mg orally bid or tid;indapamide 2.5 mg orally qd.Treatment group was given Xuefu Zhuyu decoction 100 mL · d-1,bid on the basis of control group.All patients were treated for 90 d.The clinical symptoms and blood pressure were compared before and after treatment.Results The clinical efficacy was 95.00％ (57/60 cases) and 78.33％ (47/60 cases,P ＜0.05).After treatment,the systolic blood pressure (SBP) were (130.09 ±9.95),(113.08 ±15.24) mmHg in control group and treatment group,and diastolic blood pressure (DBP) were (84.40 ±9.05),(81.02 ±6.56) mmHg (P ＜0.05).There was 1 case of dizziness in control group,and no adverse drag reaction occurred in treatment group,with no significant difference (P ＞ 0.05).Conclusion Xuefu Zhuyu decoction combined with western medicine maybe an effective treatment on elderly patients with refractory hypertension.
