Clinical trial of Trane combined with recombinant human interferon α 2b vaginal suppository in the treatment of elderly patients with low-grade cervical intraepithelial neoplasia
10.13699/j.cnki.1001-6821.2017.12.011
- VernacularTitle:派特灵联合重组人干扰素α2b栓治疗老年低度宫颈上皮内瘤变的临床研究
- Author:
Hai-Xue ZHENG
1
;
Li-Wen HU
;
Song-Ling FANG
Author Information
1. 瑞安市妇幼保健院妇科
- Keywords:
Trane;
recombinant human interferon α2b vaginal suppository;
cervical intraepithelial neoplasia;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(12):1110-1112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of Trane combined with recombinant human interferon α2b vaginal suppository in the treatment of elderly patients with low-grade cervical intraepithelial neoplasia (CIN).Methods Forty-eight elderly patients with low-grade CIN were randomly divided into control group and treatment group with 24 cases per group.Control group was given recombinant human interferon α 2b vaginal suppository 1.0 × 105 U,once two days,placed in the posterior fornix of vagina before bedtime.Treatment group was given Trane 0.5 mL,qd,local wet dressing,and 1 month after treatment changed to once every two days,on the basis of control group.Two groups were treated for 3 months.The clinical efficacy,serum levels of Chemerin,interleukin-10(IL-10) and IL-18,adverse drug reactions were compared between two groups.Results After treatment,the effective rates in treatment and control groups were 83.34％ (20/24 cases) and 54.17％ (13/24 cases) with significant difference(P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:the Chemerin were (939.47 ± 104.43),(1204.54 ± 115.34) ng · L-1;IL-10 were(210.47 ± 30.06),(262.45 ± 29.77) pg · mL-1;IL-18 were (181.23 ± 22.34),(235.34 ± 23.17) pg · mL-1,the differences were statistically significant(P ＜0.05).The adverse drug reaction in treatment group was minor local pain,which in control group was transient low-grade fever.The incidences of adverse drug reactions in two groups were 4.17％,without significant difference (P ＞ 0.05).Conclusion Trane combined with recombinant human interferon α2b vaginal suppository has a definitive clinical efficacy in the treatment of elderly patients with low-grade CIN,which can reduce the serum levels of Chemerin,IL-10 and IL-18,without increasing the incidence of adverse drug reactions.
