Research status of organic anion transport polypeptide 1B1 in transcription and protein expression regulation mechanism
10.13699/j.cnki.1001-6821.2017.11.032
- VernacularTitle:有机阴离子转运多肽1B1转录及蛋白表达调控机制的研究现状
- Author:
Yi-Fei DUAN
1
;
Yu-Qing XIONG
Author Information
1. 南昌大学临床药理研究所
- Keywords:
organic anion transport polypeptide 1B1;
pregnane X receptor;
liver X receptor;
farnesoid X receptor;
nuclear factor-kappa B
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(11):1065-1068
- CountryChina
- Language:Chinese
-
Abstract:
Organic anion transport polypeptide 1 B1 (OATP1 B1) belongs to the solute carrier(SLC) superfamily,which is mainly responsible for the transfer of internal and external substances into liver cells for metabolism.This review describes the regulation of related nuclear receptors and nuclear factor-kappa B pathway on OATP1B1 mRNA and protein expression in order to guide rational drugs use,predict drug-drug interactions,and reduce adverse drug reactions.
