Research status on microRNA-dependent control of drug transporters

VernacularTitle:MicroRNA对药物转运体调控的研究现状
Author: Gao-Feng JIN ¹ ; Yu-Qing XIONG
Author Information

1. 南昌大学临床药理研究所
Keywords: microRNA; drug transporter; adenosine triphosphate binding cassette transporter; solute carrier; post-transcriptional control
From: The Chinese Journal of Clinical Pharmacology 2017;33(11):1061-1064
CountryChina
Language:Chinese
Abstract: MicroRNA is a class of small noncoding single-stranded molecule RNA,which regulates the expression of target genes through binding with the 3'-untranslated region of target gene mRNA.In recent years,researches about microRNA regulating transporter have attracted widespread attention.With more in-depth researches,it was found that not only can microRNA directly target the mRNA of transporters,but also it can regulate some signal proteins of classic pathway to control the expression of transporters indirectly.This review summarizes the research progress of microRNAs on the regulations of several important transporters.