Research status in the regulation of calcium homeostasis mechanisms of noncoding RNAs
10.13699/j.cnki.1001-6821.2017.11.028
- VernacularTitle:非编码核糖核酸参与心脏钙稳态调控机制的研究现状
- Author:
Qiang FENG
1
;
Ya-Nan JIANG
;
Yun-Long BAI
Author Information
1. 哈尔滨医科大学药理教研室
- Keywords:
calcium homeostasis;
noncoding ribonucleic acid;
heart disease
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(11):1050-1053
- CountryChina
- Language:Chinese
-
Abstract:
The morbidity and mortality of cardiovascular diseases are increasing year by year.However,the current treatment is still not enough to solve the problem.As an important second messenger,Ca2+ homeostasis disequilibrium would lead to cellular dysfunction and metabolic disorder,which is the leading cause of cardiac function abnormalities,such as cardiac hypertrophy,atrial fibrillation,myocardial ischemia and heart failure.The ryanodine receptor 2 (RyR2),L-type calcium channel,Na +-Ca2+ exchanger (NCX) and sarcoplasmic reticulum Ca2+ ATPase -2a (SERCA2a) involve in maintaining calcium homeostasis.Unfortunately,the exact regulatory mechanism is not fully understood,leading to the limitations of its application in the treatment and prevention of heart disease.Noncoding ribonu-cleic acids (ncRNA) are a group of ribonucleic acid (RNA) molecules that could not be translated,which participate in a variety of biological functions.Clarifying the mechanism of ncRNAs in Ca2+ homeostasis will contribute to determine the susceptibility to cardiac disease,such as atrial fibrillation,halt the progression of diseases and improve the prognosis of patients.This paper reviewed the research progress on ncRNAs in Ca2+ homeostasis regulation.
