Research status of noncoding RNAs in atrial fibrillation
10.13699/j.cnki.1001-6821.2017.11.027
- VernacularTitle:非编码核糖核酸在心房颤动中的研究现状
- Author:
Yong-Qiao CAI
1
;
Ya-Nan JIANG
;
Yun-Long BAI
Author Information
1. 哈尔滨医科大学药理教研室
- Keywords:
atrial fibrillation;
micro ribonucleic acid;
long noncoding ribonucleic acid;
expression profile;
molecular mechanism
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(11):1047-1049
- CountryChina
- Language:Chinese
-
Abstract:
Atrial fibrillation (AF) is one of the most serious arrhythmias with high morbidity and mortality in clinic,which usually results in stroke,heart failure and peripheral vascular embolization,etc.Its prevalence is set to increase with widespread population ageing,causing enormous economic and social burden.Currently,medication is the common treatment method for atrial fibrillation.However,there is inefficient with a risk of arrhythmia.In recent years,noncoding ribonucleic acids (RNAs) play an important role in ontogenesis and the development of many diseases.More and more studies show that noncoding RNAs are closely related to the occurrence and maintenance of atrial fibrillation.Investigating the molecular mechanisms and interactive networks of noncoding RNAs have important significance on providing early prediction of AF susceptibility,evaluating the prognosis of patients and finding new therapeutic targets.The purpose of this report is to systematically review the molecular mechanisms of noncoding RNAs in the development and maintenance of AF.
