Inhibition effects of aqueous and ethanol extracts of Coix lacryma-jobi (L) stem on S180 tumor in mouse
10.13699/j.cnki.1001-6821.2017.11.012
- VernacularTitle:广西壮药薏苡茎提取物对小鼠S180肉瘤的抑制作用
- Author:
Jin LI
1
;
Yao LIN
;
Qiu-Ning LAN
;
Gui-Yong LI
;
Han-Bin HUO
;
Suo-Yi HUANG
Author Information
1. 右江民族医学院
- Keywords:
Coix lacryma-jobi (L) stem;
aqueous and ethanol extract;
S180 sarcoma;
anti-tumor
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(11):1000-1002
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effect of aqueous and ethanol extracts of Coix lacryma-jobi stem on the growth of mouse S180 sarcoma cells in mice.Methods Tumor growth inhibition assays were performed using both aqueous and ethanol extracts of Coix lacryma-jobi stem.Specific-pathogen-free (SPF) Kunming mice,6-8 weeks old,were inoculated with 1 × 107 cells · mL-1 S180 sarcoma cells in a volume of 0.4 mL The next day,the mice were randomly divided into blank group,control group,experimental-H,experimental-M,experimental-L doses groups,and administered with 0.9％ NaC1,cyclophosphamide (20 μg · g-1 · d-1) or Coix lacryma-jobi stem extract (1 000,500,250 mg · kg-1 · d-1) respectively by gavage or tail vein injection for 10 d.The tumor and spleen were dissected and weighed.The tumor inhibition rate was calculated.Results Tumor growth inhibition ratios in the experimental-H,experimental-M,experimental-L groups by the aqueous extract of Coix lacryma-jobi stem were 32.11％,75.63％ and 11.41％,respectively.Tumor growth inhibition ratios for experimental-H,experimental-M,experimental-L groups by the ethanol extract of Coix lacryma-jobi stem groups were 77.09％,80.03％ and 73.52％,respectively.Conclusion Each dose of water or ethanol extract of Coix iacryma-jobi stem was able to inhibit the growth of S180 sarcoma to a degree,and exhibited few adverse reactions.The optimal dose of the aqueous extract was 500 mg · kg-1 · d-1.
