Effects of Low and High Molecular Weight Hyaluronic Acids on Peridural Fibrosis and Inflammation in Lumbar Laminectomized Rats.
10.3344/kjp.2011.24.4.191
- Author:
Jun Geol LEE
1
;
Sang Chul LEE
;
Yong Chul KIM
;
Young Jin LIM
;
Jae Hyuck SHIN
;
Jae Hun KIM
;
Sang Hyun PARK
;
Yun Ra CHOI
;
Woo Seog SIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
allodynia;
failed back surgery syndrome;
hyaluronic acid;
laminectomy
- MeSH:
Animals;
Failed Back Surgery Syndrome;
Fibrosis;
Humans;
Hyaluronic Acid;
Hyperalgesia;
Inflammation;
Laminectomy;
Male;
Models, Animal;
Molecular Weight;
Rats;
Rats, Sprague-Dawley
- From:The Korean Journal of Pain
2011;24(4):191-198
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Postlaminectomy peridural fibrosis is inevitable. Some studies have compared and identified the effects of high molecular weight hyaluronic acids (HMWHA) and low molecular weight hyaluronic acids (LMWHA) on peridural fibrosis in postlaminectomy animal models. However, no studies have been found that compare pain behaviors between hyaluronic acids or among hyaluronic acids and other solid materials. The purpose of this study was to examine the correlation between pain-related behaviors and histopathologic changes in laminectomized rats using various peridurally administered materials. METHODS: Forty male Sprague-Dawley rats, laminectomized at the L5 and L6 levels, were divided into four groups: group C, laminectomy only; group L, laminectomy and LMWHA application; group H, laminectomy and HMWHA application; group F, laminectomy and fat interposition. Pain behaviors were checked before, 3 days, 1 week, and 3 weeks after surgery. Histopathological changes were checked at the L5 level 3 weeks after the surgery. RESULTS: The 50% withdrawal thresholds in groups L and H were higher than that in groups C and F three days after laminectomy (P < 0.05). The paw withdrawal time did not change among the groups and in each group during the study period. Peridural fibrosis in group F was significantly lower than in the other groups (P < 0.05). CONCLUSIONS: Hyaluronic acids significantly reduced mechanical allodynia but not thermal hyperalgesia. Peridural fibrosis did not show any correlation with pain behaviors. There have been limited studies on the correlation between peridural fibrosis and pain behavioral change, which should be verified by further studies.
