Effect of dexmedetomidine injection on analgesic in patients after thyroid surgery
10.13699/j.cnki.1001-6821.2017.11.007
- VernacularTitle:右美托咪定注射液对甲状腺手术患者术后镇痛作用的影响
- Author:
Li-Jun ZHU
1
;
Hui-Jun WANG
;
Hong-Zhu WANG
Author Information
1. 台州医院麻醉科
- Keywords:
sulfentanyl;
dexmedetomidine;
thyroid surgery;
serum β-endorphin;
interleukin-6
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(11):983-985
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of dexmedetomidine on analgesic effect in patients after thyroid surgery.Methods A total of 102 patients after thyroid surgery were divided into control group and treatment group,each group 51 cases.Patients in both groups were given thyroid operation.Patients in both groups were given sulfentanyl 10 μg + 0.375％ ropivacaine mixture 20 mL before operation,granisetron hydrochloride injection 5 mg by intravenous drip,once a day after operation.Control group was given midazolam hydrochloride injection 0.03 mg · kg-1 by intravenous drip before operation.Treatment group was received dexmedetomidine hydrochloride injection 1 μg · kg-1 by intravenous drip before operation.The clinical efficacy,3-endorphin (3-EP),interleukin-6 (IL-6),C-reactive protein (CRP) and adverse drug reactions in two groups were observed.Results After treatment,total effective rates in treatment and control groups were 92.16％ (47/51 cases) and 78.43％ (40/51 cases),with significant difference (P ＜ 0.05).After treatment,β-endorphin in control group and treatment group were (268.47 ± 29.58),(284.47±30.05) pg· L-1,CRP were (4.47 ±0.54),(4.07 ±0.42)mg · L-1(P＜0.05).The adverse drug reactions in treatment group were lethargy,respiratory depression,nausea and vomiting,the incidence of adverse drug reactions was 5.88％ (3/51 cases).The adverse drug reactions in control group were itching,respiratory depression,drowsiness,nausea and vomiting,the incidence of adverse drug reactions was 11.76％ (6/51 cases,P ＞ 0.05).Conclusion The analgesic effect of dexmedetomidine after thyroid surgery is effective with high safety.
