Trastuzumab-induced hepatotoxicity and analysis of adverse drug reaction: a case report
10.13699/j.cnki.1001-6821.2017.10.019
- VernacularTitle:1例曲妥珠单抗致肝毒性的病例报告及药物不良反应分析
- Author:
Ran XIE
1
;
Nan ZHAO
;
Yi-Min CUI
Author Information
1. 北京大学第一医院药剂科
- Keywords:
trastuzumab;
hepatotoxicity;
adverse drug reaction
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(10):936-938
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the the characteristics,risk factors and treatment of trastuzumab-induced hepatotoxicity in patients with breast cancer.Methods To analyze by a case report of trastuzumab-induced hepatotoxicity in a patient with breast cancer in practice combined with 4 related case reports in literatures.Results and conclution Trastuzumab-induced liver toxicity may have the following characteristics:early occurrence;previous use of medication with the side effect of liver damage may be one of the causes of hepatotoxicity;the grade of hepatotoxicity often reaches grade 3 and grade 4;long duration of liver function recovery;hepatotoxicity induced by trastuzumab may be dose-related.Focusing on past medical history and medication history and regular monitoring of liver function may be one of the effective measures to determine hepatotoxicity intensively and to avoid serious complications.
