Effect of propofol intravenous anesthesia on the excretion of sodium salicylate in rats
10.13699/j.cnki.1001-6821.2017.10.013
- VernacularTitle:丙泊酚静脉麻醉对大鼠水杨酸钠排泄的影响
- Author:
Hong-Bo GAO
1
;
Ji-Hui XU
;
Jin-Xue JIA
;
Wen-Yu MIAO
;
Jin-Dong QIN
;
Xue-Feng LI
;
Biao CHEN
;
Yong-Zhi XUE
Author Information
1. 包头医学院药理学教研室
- Keywords:
propofol;
blood gas analysis;
sodium salicylate;
pharmacokinetics
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(10):913-916
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of propofol intravenous anesthesia on the excretion of sodium salicylate and its mechanism in rats.Methods A total of 16 male SD rats were placed in rat metabolic cage to collect urine after intraperitoneal injection of 1％ sodium salicylate 80 mg · kg-1.Then the actual time urination and urinary volume were recorded.And salicylic acid concentration in urine were determine by spectrometry.Urine drug concentration-time curve were drawed.After 3 days of cleaning period,the rats were given intravenous injection of propofol 150 mg · kg-1 immediately after intraperitoneal injection of sodium salicylate with the former method.Urine drug concentration-time curve were drewed before and after anesthesia.Urine drug metabolism and pharmacokinetics parameters were analyzed with 3P97 Software.Sodium salicylate excretion capacity was analyzed before and after anesthesia.In experiment 3 h,the blood gas indexes were detected in the orbital venous plexus.After 3 h,blood from orbital venous was collected for analyzing the parameters of blood gas.And then,blood gas index and salicylic acid accumulation correlation analysis was eliminated.Results pH were 7.44 ± 0.04,7.37 ± 0.06 respectively before or after anesthesia by propofol intravenous.Partial pressure of carbon dioxide (PCO2) were (39.58 ± 6.42),(47.71 ± 6.80) mmHg respectively.Partial pressure of oxygen (PO2) were (88.25 ± 6.80),(67.75 ± 3.73) mmHg respectively.Base excess (BE) were (1.20 ± 1.05),(-5.08 ± 1.88) mmol · L-1 respectively.Maximum excretory rate (Rmax) were (0.62 ± 0.15),(0.39 ± 0.04) mg· h-1 respectively.Cmax were (1.43 ± 0.23),(0.85 ± 0.15) mg · kg-1 respectively.Excretion under curve (ERUC 0-28) were (25.83 ± 3.8),(17.35 ± 2.01) mg · h · L-1 respectively,the difference was statistically significant (all P ＜0.05).Statistically significant positive correlation was presented between pH,PO2,BE and accumulated with salicylic acid excretion (P ＜ 0.05).And R2 were respectively 0.9758,0.9760,0.9398.At the same time,the obvious negative correlation was observed between PCO2 and salicylic acid accumulation excretion,R2 was 0.902 3,it was statistical significance (P ＜0.05).Conclusion Propofol intravenous anesthesia can slow down the rate of sodium salicylate excretion,and significantly related to parameters of blood gas.
