Analysis the short and long-term effectiveness of glucocorticoid in the treatment of eosinophilic granulomatosis with polyangiitis
10.13699/j.cnki.1001-6821.2017.10.007
- VernacularTitle:糖皮质激素治疗嗜酸细胞肉芽肿性多血管炎的近期与远期疗效分析
- Author:
Yi-Zhuo GAO
1
;
Xiao-Xue GUO
;
Jing-Jing FAN
;
Rui YE
;
Li ZHAO
Author Information
1. 中国医科大学附属盛京医院第一呼吸内科
- Keywords:
eosinophilic granulomatosis with polyangiitis;
glucocorticoid;
involved organs
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(10):888-892
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the short-term and long-term clinical effect of eosinophilic granulomatosis with polyangiitis (EGPA) patients treated with corticosteroids and/or immunosuppressants.Methods A total of 36 cases who fulfilled the eosinophilic granulomatosis with polyangiitis diagnosis from January 2008 to February 2016 were collected including their information and the acute clinical symptoms as well as laboratory findings before and after treatment to evaluate short-term effect.We also evaluated the long-term effect by outpatient or telephone at September 2016.All patients were treated with drugs,including but not limited to corticosteroids,others consisting of immunosuppressants such as cyclophosphamide,azathioprine;glucocorticoid dosage based on the severity and effects,corticosteroids including intravenous and oral form,immunosuppressants for intravenous form.Results We assessed short-term effectiveness by 32 patients with initial pure glucocorticoid treatment,clinical symptoms were improved.The eosinophils before and after treatment were (1.48 ± 0.81) × 109/L,(0.22 ± 0.36) × 109/L;percentage of eosinophils were (17.35 ± 8.50)％,(2.95 ± 4.90)％;total immunoglobulin E were (750.95 ± 1040.11),(343.87 ± 489.53) U · mL-1;C reactive protein were (44.44 ± 37.65),(17.80 ± 13.29)mg · L-1;erythrocyte sedimentation rates were (58.25 ± 40.61),(23.55-± 10.34) mm · h-1 Five-factors score (FFS) showed that higher scores meant more recurrence,which meant bad long-term effectiveness.Conclusion Important organ involvement indicated poor efficacy of long-term glucocorticoid treatment,which required immunosuppressants therapy as early as possible in order to reduce the recurrence.
