Clinical trial of bromfenac sodium eye drop in the treatment of postoperative inflammation of cataract
10.13699/j.cnki.1001-6821.2017.10.004
- VernacularTitle:溴芬酸钠滴眼液治疗白内障术后炎症的临床研究
- Author:
Zhi-Shu BAO
1
;
Jin LI
;
Yin-Fei YU
;
Gong-Min SHEN
;
Yan JIN
;
Yun-E ZHAO
Author Information
1. 温州医科大学附属眼视光医院药物临床试验中心
- Keywords:
bromfenac sodium eye drops;
cataract surgery;
inflammation
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(10):877-879,883
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinical efficacy and safety of domestic and imported bromfenac sodium eye drops in the treatment of posto-perative inflammation of cataract.Methods A total of 134 cataract patients were divided into treatment group (n =66) and control group (n =68).Control group was treated with imported bromfenac sodium eye drops,and treatment group was given domestic bromfenac sodium eye drops,1 drop in morning and evening respectively.All patients were treated for 14 d.The clinical efficacy and adverse drug reactions in two groups were compared.Results After treatment,the cured rate and effective rate in treatment group were 53.97％ (34/63 cases),46.03％ (29/63 cases).The cured rate and effective rate in control group were 67.74％ (42/62 cases),32.26％ (20/62 cases).There was no significant difference between two groups (P ＞ 0.05).There were no statistical differences between the two groups in ocular tolerance,burning sensation,ophthalmic itching and corneal epithelium spotting at 3,7,14 d after treatment (P ＞ 0.05).There were 1 case of eye discomfort,2 cases of liver function abnormal and 2 cases of urine leukocyteabnormalin control group,with the incidence rate of 7.35％ (5/68 cases).There were 1 case of infection in urinary system,1 case of dizziness,1 case of pathogenesis of primary acute angle-closure glaucoma in right eye,1 case of floating cells in anterior chamber,with the incidence rate of 6.06％ (4/66 cases,P ＞0.05).Conclusion The clinical efficacy of domestic bromfenac sodium eye drops in the treatment of cataract patients is comparable to imported bromfenac sodium eye drops.The clinical efficacy is exactly,with lower adverse drug reactions and price.
