Clinical trial of esomeprazole enteric-coated tablets combined with Lizhong pill in the treatment of gastric ulcer
10.13699/j.cnki.1001-6821.2017.10.002
- VernacularTitle:埃索美拉唑肠溶片联合理中丸治疗胃溃疡的临床研究
- Author:
Dong-Li HE
1
;
Yi-Ni ZHANG
;
Qing-Shan QU
Author Information
1. 南阳市中心医院消化内科
- Keywords:
esomeprazole enteric-coated tablet;
Lizhong pill;
gastric ulcer;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(10):870-872
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of esomeprazole enteric-coated tablets combined with Lizhong pill in the treatment of gastric ulcer.Methods Fifty-four patients of gastric ulcer were randomly divided into control group (n =27 cases) and treatment group (n =27 cases).Control group was treated with esomeprazole 40 mg oral,tid.On the basis of control group,treatment group was given Lizhong pill 9 g oral,bid.Two groups were treated for 14 d.The clinical efficacy,levels of serum interleukin-8 (IL-8),tumor necrosis factor-α (TNF-α),vascular endothelial growth factor (VEGF),basic fibroblast growth factor (bFGF),and the occurrence of adverse drug reactions were compared between two group.Results After treatment,the total effective rates in treatment and control groups were 92.59％ (25/27 cases) and 70.37％ (19/27 cases),with significant difference (P ＜ 0.05).After treatment,in treatment and control groups,the levels of serum IL-8 were (15.85 ±2.08),(19.37 ±2.11) pg · mL-1;TNF-α were (70.75-±10.05),(82.65 ±11.03)pg · mL-1,there was statistically significant difference (P ＜ 0.05).After treatment,the levels of VEGF were (473.54 ± 50.78),(456.31 ± 51.57) pg · mL-1;bFGF were (567.43 ± 63.24),(540.86 ±58.67)pg · mL-1 in the treatment and control groups,respectively,with no significant difference (P ＞ 0.05).The adverse drug reactions were abdominalgia,sicchasia and rashes in two groups.The incidences of adverse drug reactions in treatment and control groups were 11.11％ and 18.52％,and there was no statistically significant difference (P ＞ 0.05).Conclusion Esomeprazole enteric-coated tablets combined with Lizhong pill has a definitive clinical efficacy in gastric ulcer treatment,and without increasing the incidence of adverse drug reactions.
