Clinical trial of Xingnaojing injection combined with atorvastatin calcium in the treatment of acute cerebral hemorrhage
10.13699/j.cnki.1001-6821.2017.09.002
- VernacularTitle:醒脑静注射液联合阿托伐他汀钙胶囊治疗急性脑出血的临床研究
- Author:
Yu-Qing HE
1
;
Li-Ping WEI
;
Wen-Bo LI
;
Yao-Hui ZHANG
;
Hong-Li PANG
;
Peng YAN
Author Information
1. 洛阳市中心医院神经内科
- Keywords:
Xingnaojing injection;
atorvastatin calcium;
acute cerebral hemorrhage;
interleukin-1 β;
superoxide dismutase
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(9):774-777
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of Xingnaojing injection combined with atorvastatin calcium in the treatment of acute cerebral hemorrhage.Methods A total of 68 cases with acute cerebral hemorrhag were divided into control group and treatment group,each group 34 cases.Patients in both groups were given regular treatment.Patients in control group were orally given atorvastatin calcium capsules 20 mg,once a day.Patients in treatment group were received Xingnaojing injection 20 mL by intravenous drip,twice a day on the basis of control group.All patients were treated for 21 d.The clinical efficacy,C reactive protein (CRP),interleukin-1β (IL-1 β),tumor necrosis factor-α (TNF-o),nitric oxide (NO),malondialdehyde (MDA),superoxide dismutase (SOD) and adverse drug reactions were compared in two groups.Results The clinical efficacy in treatment group was 94.12％ (32/34),had significant difference with that in control group,which was 76.47％ (26/34,P ＜0.05).After treatment,the serum CRP of treatment group and control group were (3.72 ±0.86),(5.18 ±0.51)mg· L-1,IL-1β were (4.02 ±0.41),(5.48 ±0.58)ng· L-1,TNF-αwere (19.47 ±2.13),(29.59 ±3.04) μg· L-1,NO were (3.03 ±0.34),(4.11 ±0.42) ng· L-1,MDAwere (6.04 ±0.61),(7.17 ±0.76) μmol · mL-1,SOD were (162.01 ± 16.34),(142.63 ±14.64)U · mL-1 (P ＜ 0.05).In treatment group,patients had headache,nausea,rash,incidence of adverse drug reactions was 8.82％ (3/34 cases).In control group,patients had headache,vision fuzzy,nausea,insomnia,incidence of adverse drug reactions was 14.70％ (5/34 cases,P ＞ 0.05).Conclusion Xingnaojing injection combined with atorvastatin calcium in the treatment of acute cerebral hemorrhag was effective with high safety.
