Analysis of serum trough concentration monitoring and clinical use of vancomycin in patients
10.13699/j.cnki.1001-6821.2017.09.001
- VernacularTitle:万古霉素血清谷浓度监测及临床应用分析
- Author:
Cui-Hong WANG
1
;
Ting LUAN
;
Rui YE
;
Xiao-Jie WU
;
Li ZHAO
Author Information
1. 中国医科大学附属盛京医院呼吸科
- Keywords:
vancomycin;
serum trough concentration;
nephrotoxicity
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(9):771-773,777
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical application of vancomycin and thestatus quo of vancomycin serum trough concentration in our hospital intensive care unit (ICU) patients.Methods Fluorescence polarization immunoassay was used for vancomycin serum trough concentration test.The clinical information (primary diseases,bacteriological culture,vacomycin serum trough concentration,clinical efficacy,renal function) of 204 adult ICU inpatients who had been treated with vancomycin and their serum concentration were analyzed retrospectively.Results The bacteria detection rate was 25.6％.The drug indications bacteriology coincidence rate was 41.6％.The clinical cure rate was 70.6％.And 275 serum vancomycin trough concentration data were collected from 204 ICU inpatients.The values of vancomycin serum trough concentration were 1.11-50 μg · mL-1,with an average of (13.32 ± 8.40)μg· mL-1.The rate was 14.5％ of target concentration 15-20μg · mL-1.Forty-two patients (20.6％) experienced nephrotoxicity,and four patients (2.0％) could not be judged due to insufficient data.Conclusion The value of vancomycin serum trough concentration of the 204 cases were less in effective range which should be paid attention to the serum concentration monitoring of ICU inpatients to achieve an ideal individual administration according to clinical practice.
