Expression of CCAAT-enhancer-binding proteins in colon cancer and its significance
10.13699/j.cnki.1001-6821.2017.08.020
- VernacularTitle:CCAAT增强子结合蛋白-α在结肠癌中的表达及意义
- Author:
Xu-Quan CHEN
1
;
Hong-Zhong ZHOU
;
Yan-Le NI
;
Zhi-Yong ZHANG
;
Long YE
Author Information
1. 乐清市第二人民医院普外科
- Keywords:
colon cancer;
expression;
prognosis
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(8):745-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and clinical significance of CCAAT-enhancer-binding proteins (C/EBPα) in colon cancer tissues.Methods The expression level of C/EBPoα in colon cancer tissues and corresponding non-tumor normal tissues of 41 colon cancer patients was detected by Western blot.The correlation between the expression of C/EBPoα and clinicopathological parameters of colon cancer and survival rate of prognosis were statistically analyzed.Results In 41 cases of normal tissue adjacent to carcinoma,low expression of C/EBPeα appeared only 2 cases,high expression 39 cases,low expression rate was only 4.88％;and in 41 cases of colon cancer,C/EBP low expression appeared 32 cases,high expression only 9 cases,low expression rate was 78.05％.Compared with normal adjacent tissues,the expression of C/EBP in colon cancer was down regulated (P＜0.05).In 41 cases of colon cancer,independent of C/EBPα expression and colon cancer,cancer size,sex,age and histological classification of colon cancer clinical pathological parameters (P ＞ 0.05),but tumor node metastasis (TNM) and colon cancer staging was closely related (P ＜ 0.05).The median survival times in low expression and high expression groups were 31.5 and 54.2 months,with significant difference(P ＜0.05).Conclusion The low expression of C/EBPα in colon cancer has a close relationship with TMN staging and survival rate of prognosis,which has a great significance on early diagnosis and targeted therapy of colon cancer in the future.
