Effects of the extracts of Chinese Angelica and Milkvetch root on the absorption of Ginsenoside in rats
10.13699/j.cnki.1001-6821.2017.07.013
- VernacularTitle:当归和黄芪提取物对大鼠体内人参皂苷吸收的影响
- Author:
He YE
1
;
Jing-Ling WU
;
Gui-Yuan LV
;
Li LI
Author Information
1. 浙江医院药剂科
- Keywords:
ginsenoside;
Chinese Angelica;
Milkvetch root;
chromatogram of plasma;
absorption;
RP-HPLC
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(7):620-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of extracts of Chinese Angelica and Milkvetch root on the absorption of ginsenoside in rats.Methods A total of 12 female SD rats were randomly divided into four groups:Ginseng-experimental group(Ginseng extract 8.0 g · kg-1 · d-1),Chinese Angelica-experimental group (Chinese Angelica extract 3.2 g · kg-1 · d-1),Milkvetch root-experimental group (Milkvetch root extract 16.0 g · kg-1 · d-1) and combination-experimental group (Ginseng extract 8.0 g · kg-1 d-1 + Chinese Angelica extract 1.6 g · kg-1 · d-1 +Milkvetch root extract 8.0 g · kg-1 · d-1),3 rats in each group.Rats were weighed,after an overnight fast,the extracts were intragastrical administration on the next day.Blood samples were drawn from orbit at 1 h,2 h,3 h after administration.The peak areas of ginsenoside Rb1 (G-Rb1),ginsenoside Rc (G-Rc),ginsenoside Rb2 (G-Rb2) and ginsenoside Rd (G-Rd) in fossa orbitalis plasma were measured in four groups with reversed phase-HPLC.And the differences of concentrations between groups were compared.Results By comparison of the concentrations of ginsenosides in Ginseng-experimental group,Chinese Angelica-experimental group,Milkvetch root-experimental group and combination-experimental group,it was found that the contents of G-Rb1,G-Rc,G-Rb2 and G-Rd in combination-experimental group were much higher than that in Ginseng-experimental group (data was not detected).Conclusion Extracts of Chinese Angelica and Milkvetch root have some promotion effects on the absorption of ginsenosides.
