Clinical trial of progesterone combined with nifedipine in the treatment of upper ureteral calculi
10.13699/j.cnki.1001-6821.2017.07.005
- VernacularTitle:黄体酮注射液联合硝苯地平片治疗输尿管上段结石的临床研究
- Author:
Se-Lan HUANG
1
;
Yan-Le YE
;
Yi-Tian SHEN
Author Information
1. 泉州市第一医院碎石中心
- Keywords:
progesterone;
nifedipine;
ureteral calculi;
C-reactive protein;
interleukin-6
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(7):592-594
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of progesterone combined with nifedipine in the treatment of upper ureteral calculi.Methods A total of 94 patients with upper ureteral calculi werc divided into control group and treatment group,47 cases in cach group.Patients in control group were given anisodamine hydrochloride injection 5-10 mg by intramuscular injection,qd.Patients in treatment group received progesterone injection 20 mg by intramuscular injection,bid and nifedipine tablets 10 mg by under tongue,tid.All patients were treated for 14 d.The clinical efficacy,C-reactive protein(CRP),interleukin-6 (IL-6) and adverse drug reactions were compared between the two groups.Results The clinical efficacy in treatment group was 95.74％ (45/47 cases),had significant difference with that in control group,which was 82.98％ (39/47 cases,P ＜0.05).The levels of CRP and IL-6 in treatment group were (2.17 ± 0.25) mg · L-1,(4.72 ± 0.51) ng · L-1,had significant difference with those in control group,which were(3.45 ±0.42) mg· L-1,(8.34±0.89) ng · L-1 (P ＜0.05).The main adverse drug reactions in treatment group were dry mouth,blurred vision and rashes,the incidence rate was 6.38％ (3/47 cases).The main adverse drug reactions were dry mouth,rapid heart beat,difficulty urinating and rashes in control group,the incidence rate was 10.64％ (5/47 cases,P ＞ O.05).Conclusion Progesterone combined with nifedipine in the treatment of upper ureteral calculi was effective with high safety.
