Study on the association between cytochrome P450 2C19, PON1 and ABCB1 gene polymorphism and clopidogrel resistance
10.13699/j.cnki.1001-6821.2017.07.003
- VernacularTitle:细胞色素P450 2C19、PON1及ABCB1基因多态性与氯吡格雷抵抗的关联分析
- Author:
Xin LIANG
1
;
Shi-Cai CHEN
;
Bin-Bin XIA
;
Liu-Shui LI
;
Jing CHEN
;
Ya-Li LI
;
Xin LIU
Author Information
1. 首都医科大学附属北京潞河医院药剂科
- Keywords:
acute coronary syndrome;
clopidogrel;
cytochrome P450 2C19;
PON1;
ABCB1;
gene polymorphism
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(7):585-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlation of clopidogrel resistance and gene polymorphisms of cytochrome P450 2C19 (CYP2C19),PON1 and ABCB1.Methods Gene types of CYP2C19 * 2,* 3,* 17,PON1 and ABCB1 in 175 patients with PCI acute coronary syndrome (ACS) were detected by fluorescence in situ hybridization.Platelet aggregation rate was determined by thromboela-stogram.Patients with platelet aggregation rate ＞50％ were enrolled in clopidogrel resistance group,while those with platelet aggregation rate ≤ 50％ were in clopidogrel sensitive group.Results ACS patients with CYP2C19 * 2 or * 3 heterozygote mutations were associated with a significant increase in the risk of clopidogrel resistance when compared to wild type.CYP2C19 * 2/* 2 and * 2/* 3 were at higher risk of clopidogrel resistance.The mutation rate of PON1 gene was 59.43％,in which the homozygous mutant was 15.43％.The mutation rate of ABCB1 gene was 60.57％,in which the homozygous mutant took up 14.86％.The incidence of clopidogrel resistance was not significantly affected though the mutation rates were high.Conclusion CYP2C19 * 2 or * 3 mutations were associated with clopidogrel resistance in PCI postoperative ACS patients.There was no significant correlation between PON1 and ABCB1 gene.
