Clinical trial of naloxone injection in the treatment of acute left heart failure
10.13699/j.cnki.1001-6821.2017.07.002
- VernacularTitle:纳洛酮注射液治疗急性左心衰竭的临床研究
- Author:
Shao-Dan FENG
1
;
Yong JIANG
;
Yi-Long WU
;
Zhi-Hong LIN
;
Si-Ming LIN
;
Pei-Hong LIN
Author Information
1. 福建医科大学附属第一医院急诊科
- Keywords:
naloxone injection;
acute left heart failure;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(7):582-584
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of naloxone injection in the treatment of acute left heart failure.Methods A total of 60 patients with acute left heart failure were randomly divided into control group and the treatment group with 30 cases per group.Control group received cardiotonic,diuretic,oxygen inhalation and anti-infective therapy.Treatment group was given naloxone treatment with intravenous infusion,on the basis of the control group.The first dose of naloxone was 0.8 mg,followed by naloxone 1.2 mg qd,if necessary,increasing the naloxone 0.8 mg after the first intravenous infusion 2-4 h for 3 d.Two groups were treated until thesymptoms of left ventricular failure was relieved.The clinical efficacy,beta endorphin (β-EP),brain natriuretic peptide(BNP),cardiac troponin Ⅰ (cTn-Ⅰ),stroke volume (SV),left ventricular ejection fraction (LVEF),and adverse drug reactions were compared between two groups.Results After treatment,the effective rates of treatment and control groups were 90.00％ (27/30 cases) and 63.33％ (19/30 cases) with significant difference (P ＜ 0.05).24,48,72 h after treatment,β-EP in treatment group were (40.07 ± 7.25),(31.31 ±6.57),(25.82 ± 5.44)ng · L-1,which in control group were (53.78 ± 5.98),(48.74 ± 5.94),(41.68 ±6.65)ng · L-1,the differences were statistically significant (P ＜ 0.05).24 h after treatment,BNP in treatment and control groups were (216.68 ± 39.40),(312.20 ± 51.47) ng · L-1;eTn-Ⅰ were (0.09 ± 0.04),(0.19 ±0.03) μg · L-1;SV were (83.58 ±5.66),(74.63 ±6.61) mL;LVEF were (50.04 ±6.36)％,(41.02 ± 5.81) ％,with significant differences (P ＜ 0.05).There was 1 case of vomiting in the treatment group and no adverse drug reaction in the control group,the incidences of adverse drug reactions in treatment and control groups were 3.33％ and 0 respectively without significant difference (P ＞ 0.05).Conclusion Naloxone injection has a definitive clinical efficacy in the treatment of acute left heart failure,which can significantly reduce the level of patients' β-EP and improve myocardial injury and cardiac function,without increasing the incidence of adverse drug reactions.
