Clinical trial of tranexamic acid tablets combined with glutathione and coltagen in patients with chloasma
10.13699/j.cnki.1001-6821.2017.06.021
- VernacularTitle:氨甲环酸片联合谷胱甘与胶原贴对黄褐斑患者的临床研究
- Author:
Zi-Jin QIU
1
;
De-Qing CHEN
Author Information
1. 重庆医药高等专科学校医学美容教研室
- Keywords:
tranexamic acid;
glutathione;
collagen;
chloasma
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(6):558-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and melisma area severity index (MASI) score of tranexamic acid combined with glutathione,coltagen effect in patients with chloasma.Methods A total of 110 patients with chloasma were randomly divided into control group and treatment group,each group 55 cases.Control group was treated with glutathione combined with collagen patch applying,glutathione injection 1.2 g add 0.9％ NaCl or 5％ glucose injection 250 mL,intravenous drip,drip speed normal;collagen dressing with 30 min treatment,2 times a week,8 weeks a courses.Treatment group was treated with oral ammonia tranexamic acid tablets 250 mg based on control group,2 times a day,and last for 2 months.Compared the clincial efficacy and MASI score between the two groups.Results The total efficacy in treatment group was 87.27％ (48/55),had significant difference with that in control group,which was 69.09％ (38/55,P ＜ 0.05).Mter 2,4,6 months,MASI scores in control group were 10.42 ± 3.39,7.94 ± 2.36,6.97 ± 1.30,had significant difference with those in treatment group,which were 9.17 ±2.86,6.38 ±2.87,5.14 ±1.30 (P ＜0.05).Patients in treatment group had 1 case of nausea,without special treatment,and no adverse drug reactions occurred in control group.Conclusion Tranexamic acid combined with glutathione,collagen paste can obviously improve the chloasma patients with psoriasis area and severity,the curative effect is remarkable.
