Clinical trial of mouse nerve growth factor in the treatment with senile dementia
10.13699/j.cnki.1001-6821.2017.06.003
- VernacularTitle:注射用鼠神经生长因子治疗老年痴呆患者的临床研究
- Author:
Nian-Ping HUANG
1
;
Lian FU
;
Zhi-Hong DENG
Author Information
1. 恩施土家族苗族自治州民族医院
- Keywords:
mouse nerve growth factor;
senile dementia;
cytokine;
prognosis
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(6):490-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect and serum cytokines levels of mouse nerve growth factor during the treatment of senile dementia.Methods A total of 90 senile dementia patients were randomly divided into treatment group and control group,each group 45 cases.Control group was given conventional treatment.Treatment group was intravenous drip mouse nerve growth factor 20 μg,qd on the basis of control group.All patients were treated for 6 weeks.The cognitive function,dementia degree,daily life ability before treatment and 6,12 weeks after treatment in two groups were observed.The levels of serum interleukin-1β (IL-1β),interleukin-6 (IL-6),C-reactive protein(CRP),tumor necrosis factor-α (TNF-α) in two group were observed.Results The mental state examination(MMSE),activity of daily life (ADL),clinical dementia rating (CDR) in two group after 12 weeks treatment had significant difference (P ＜ 0.05).The IL-1 β in treatment group after 6,12 weeks treatment were (20.88 ± 5.83),(18.35 ±3.96) ng · L-1,and were (21.12 ±6.12),(20.76 ±4.83) ng· L-1 in control group.The IL-6 in treatment group after 6,12 weeks treatment were (24.33 ± 8.56),(18.85 ±5.83) ng · L-1,and were (24.84 ±9.13),(21.64 ± 6.68) ng · L-1 in control group.The CRP in treatment group after 6,12 weeks treatment were (6.43 ± 1.65),(5.27 ± 0.63)ng · L-1,and were (6.73 ± 1.73),(6.17 ± 0.95) ng · L-1 in control group.The TNF-α in treatment group after 6,12 weeks treatment were (40.52 ±8.33),(36.34 ±5.92) ng · L-1,and were (40.85 ±9.15),(39.46 ±6.44) ng · L-1 in control group.The IL-1β,IL-6,CRP,TNF-α in two group after 12 weeks treatment had significant difference (P ＜0.05).There was 1 case of mild headache in control group,the incidence of adverse drug reactions was 0.02％ (1/45 cases).There was no adverse drug reaction occurred in treatment group.Conclusion The clinical effect of nerve growth factor in the treatment of senile dementia is significant,and can improve the living ability,relieve the symptoms of dementia,reduce the level of serum cytokines.
