Clinical trial of Danshen dripping pill in the treatment of diabetic coronary heart disease
10.13699/j.cnki.1001-6821.2017.06.002
- VernacularTitle:丹参滴丸治疗糖尿病性冠心病的临床研究
- Author:
Si-Jia HU
1
;
Ying-Zhi PENG
;
Yang YU
;
Jun ZHOU
Author Information
1. 浙江医院
- Keywords:
Danshen dripping pill;
atorvastatin calcium tablet;
metformin tablet;
diabetic coronary heart disease;
insulin resistance
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(6):486-489
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of Danshen dripping pill combined with atorvastatin calcium tablets and metformin hydrochloride tablets in the treatmem of diabetic coronary heart disease.Methods Ninety-four patients with diabetic coronary heart diseases were randomly divided into control group (n =47 cases) and treatment group (n =47 cases).Control group was treated with atorvastatin calcium 20 mg qd + metformin hydrochloride 0.5 g tid.Treatment group was given Danshen dripping pill 270 mg per time,tid,on the basis of the control group.Two groups were treated for 3 months.The clinical efficacy,the levels of serum total cholesterol (TC),triglycerides (TG),low-density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol(HDL-C),hemoglobinA1 c (HbA1 c),fasting blood glucose (FBG) and adverse drug reactions were compared between two groups,and the homeostasis model assessment insulin resistance (HOMA-IR) were calculated.Results After treatment,the total effective rates in treatment and control groups were 91.49％ (43/47 cases) and 74.47％ (35/47 cases) with significant difference(P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:TC were (3.05 ±0.21),(3.55 ±0.16)mmol · L-1;TG were(1.14 ± 0.16),(1.45 ± 0.14) mmol · L-1;LDL-C were(1.42 ±0.19),(1.74±0.19) mmol · L-1;HDL-C were(1.11 ±0.12),(1.40 ±0.15) mmol · L-1;HbA1c were (4.09 ± 0.50) ％,(5.06 ± 0.71) ％;FBG were (4.68 ± 0.61),(5.42 ± 0.93) mmol · L-1;HOMA-IR were (2.63 ±0.60),(3.66 ±0.59),the differences were statistically significant(P ＜0.05).The adverse drug reactions in two groups were based on increasing transaminase,flatulence,constipation,acute myocardial infarction,and so on.The incidences of treatment and control groups were 31.94％ and 34.04％ without significant difference (P ＞ 0.05).Conclusion Danshen dripping pill combined with atorvastatin calcium tablets and mefformin hydrochloride tablets has a definitive clinical efficacy in the treatment of diabetic coronary heart disease,which can improve the levels of blood lipid and function of islet cells,decrease blood glucose,without increasing the incidence of adverse drug reactions.
