Clinical trial of pantoprazole sodium injection combined with clopidogrel tablets in the treatment of acute myocardial infarction with gastrointestinal bleeding
10.13699/j.cnki.1001-6821.2017.06.001
- VernacularTitle:泮托拉唑钠注射剂联合氯吡格雷片治疗急性心肌梗死伴消化道出血的临床研究
- Author:
Yue-Qin QIAO
1
;
Hong-Wei XU
;
Qing WANG
;
Hui-Ling ZHAO
Author Information
1. 青岛市第九人民医院消化内科
- Keywords:
pantoprazole sodium injection;
clopidogrel tablet;
acute myocardial infarction;
gastrointestinal bleeding;
prostaglandin E2
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(6):483-485,489
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of pantoprazole sodium injection combined with clopidogrel tablets in the treatment of acute myocardial infarction with gastrointestinal bleeding.Methods Forty-four patients of acute myocardial infarction with gastrointestinal bleeding were randomly divided into control group and treatment group with twenty-two cases per group.Control group was given clopidogrel 75 mg qd oral + omeprazole 20 mg bid oral.Treatment group was given clopidogrel 75 mg qd oral + pantoprazole sodium 40 mg qd intravenous infusion.Two groups were treated for 7 d.The clinical efficacy,levels of prostaglandin E2,cardiovascular adverse events and adverse drug reactions were compared between two groups.Results Mter treatment,the total effective rates in treatment and control groups were 86.36％ (19/22 cases) and 59.90％ (13/22 cases) with significant difference (P ＜0.05).At the time of the 3,5,7 d after treatment,the prostaglandin E2 in treatment group were (81.03 ± 18.48),(116.70 ± 21.93),(149.93 ± 27.52) ng · mL-1,which in control group were (67.09 ± 15.20),(92.56 ± 16.34),(120.08 ± 20.05) ng · mL-1,with statistically significant difference (P ＜ O.001).Follow-up of 3 months,the incidences of cardiovascular adverse events in two groups were 18.18％ without significant difference (P ＞0.05).The adverse drug reactions in treatment group were constipation,atopic dermatitis,decreased renal function,which in control group were constipation and atopic dermatitis.The incidences of adverse drug reactions in treatment and control groups were 18.18％ and 13.64％ without significant difference (P.＞0.05).Conclusion Pantoprazole sodium injection combined with clopidogrel tablets has a definitive clinical efficacy in the treatment of acute myocardial infarction with gastrointestinal bleeding,which can improve the level of prostaglandin E2,without increasing the incidences of cardiovascular adverse events and adverse drug reactions.
