Clinical investigation of 144 patients with drug-induced liver injury and its influencing factors analysis
10.13699/j.cnki.1001-6821.2017.05.023
- VernacularTitle:144例药物性肝损伤的临床特点及影响因素分析
- Author:
Pei-Pei MENG
1
;
Shi-Kun LIU
;
Yang HE
;
Yu-Tao MA
;
Shan-Ru ZUO
;
Li-Ying SONG
;
Chun-Jiang WANG
Author Information
1. 中南大学湘雅三医院药剂科
- Keywords:
drug-induced liver injury;
adverse drug reaction;
anti-tuberculosis drugs;
immunosuppressive agents
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(5):467-469,473
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to provide support for the rational use of drugs,we summarize the clinical characteristics of patients with drug-induced liver injury (DILI) and statistics of the allergic drugs.Methods According to the common drug-induced liver injury diagnostic criteria of our country,the clinical data of 144 hospitalized cases in the third Xiangya hospital with DILI were analyzed retrospectively,then,potential pathogenic drugs were summarized.Results A total of 144 patients with DILI were enrolled in this study:male account for 53.47％ (77/144 cases),female account for 46.53％ (67/144 cases).The average age was (44.32 ± 16.02) years old,and 50.70％ (73/144 cases) of the patients were over 40 years old.Liver injury was caused by several kinds of drugs,23.61％ (34/144 cases) were traditional Chinese medicine,20.83％ (30/144 cases)were immunosuppressive agents,15.97％ (23/144 cases) were anti-tuberculosis drugs,7.64％ (11/144 cases) were antineoplastic drugs.18.75％ (27/144 cases) patients were cured,22.92％ (33/144 cases) patients got better while others account for 58.33％ (84/144 cases),and the average hospitalization days of patients with DILI were 16 days.Age,gender and duration of the disease had no significant effect on prognosis (P ＞ 0.05),while there were significant differences between liver function indexes and prognosis (P ＜0.05).Conclusion In this study,the incidence of DILI was higher in elderly people.A variety of drugs were able to cause DILI,including traditional Chinese medicine,immunosuppressive agents and anti-tuberculosis drugs.
