Correlation between patients with coronary heart disease and the level of high-sensitivity C-reactive protein and brain natriuretic peptide and adiponectin level
10.13699/j.cnki.1001-6821.2017.05.022
- VernacularTitle:超敏C反应蛋白和脑钠肽及脂联素水平与冠心病患者相关性
- Author:
Yong-Jun LIN
1
;
Chun-Fang WU
;
Zhi-Rong YE
;
Da-Jun CHAI
Author Information
1. 泉州市第一医院老年病科
- Keywords:
C-reactive protein;
brain natriuretic peptide;
adiponectin;
coronary heart disease
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(5):463-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of high-sensitivity C-reactive protein(hs-CRP),brain natriuretic peptide (BNP),adiponectin (APN) on coronary heart disease(CHD) occurrence,clinical course and prognosis,as well as the correlation among different types of coronary heart disease.Methods A total of 528 cases were divided into control group (same period of healthy volunteers) with 250 cases and the treatment group (CHD patients) with 278 cases,and the treatment group was divided into three groups according to clinical types of coronary heart disease:acute myocardial infarction (AMI) group with 40 cases,unstable angina pectoris (UPA) group with 121 cases,stable angina pectoris (SAP) group with 117 cases.In treatment group,the serum hs-CRP concentration were detected by latex immune ratio;and the serum BNP concentration was determined by chemiluminescence microparticle immuno assay;the serum APN concentration was measured by ELISA.Results In control group and treatment group,the serum hs-CRP were (3.78 ±2.12),(7.29 ±5.98) mg · L-1,the difference was statistically significant (P ＜ 0.05);the serum APN content division ratio of (81.21 ± 20.89),(1423.89 ± 1389.21) pg · mL-1,the difference was statistically significant (P ＜0.05);the serum BNP levels were (929.23 ± 312.67),(412.34 ±299.89) μg · mL-1,the difference was statistically significant (P ＜0.05).In the treatment group of coronary heart disease,hs-CRP concentration and BNP were not correlated,the difference was not statistically significant (P ＞ 0.05).There was a negative correlation (r =-0.567) and a statistically significant (P ＜0.05) between hs-CRP and APN.No correlation and no significant difference were found between BNP and APN (P ＞ 0.05).Conclusion The serum hs-CRP,APN and BNP levels were closely related to the development of coronary heart disease,thus they are considered as risk factors for coronary heart disease.
