Correlation between calcineurin inhibitor drug-induced chronic nephrotoxicity in patient after kidney allograft and the CYP3A4 * 1G gene polymorphism
10.13699/j.cnki.1001-6821.2017.05.005
- VernacularTitle:细胞色素CYP3A4 * 1G基因多态性与肾移植患者术后发生钙调神经蛋白抑制剂慢性肾毒性的相关性
- Author:
Ze-Qing BAO
1
;
Shu-Jin ZHAO
;
Yun-Song ZHU
;
Lei SHI
Author Information
1. 肇庆医学高等专科学校药理教研室
- Keywords:
chronic nephrotoxicity;
calcineulin inhibitor;
cytochrome P4503A4 * 1G;
polymorphism
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(5):401-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the relationship between CYP3A4 * 1G genetic polymorphism with calcineurin inhibitor(CNI)-induced chronic nphrotoxicity in Chinese population.Methods Blood samples and clinical data were collected from 200 Chinese patients with CNI drug-induced chronic nephrotoxicity as treatment group and 200 Chinese kidney allograft recipients without chronic nephrotoxicity as the control.DNA was extracted from the blood samples of patients in two groups,and the frequencies of CYP3A4 * 1G genotypes were analyzed using polymerase chain reaction-restriction fragment length polymorphism.The relationship between the polymorphisms of CYP3A4 * 1G and the CNI drug-induced chronic nephrotoxicity was analyzed.Results The frequencies of the 3 gene types CYP3A4 * 1G RsaI 1/1,1/1G,and 1G/1G were 51％ (102/200),34.5％ (69/200) and 14.5％ (29/200) respectively in patients with CNI drug-induced chronic nephrotoxicity (treatment group),and49.5％ (99/200),45％ (90/200),and5.5％ (11/200) respectively in the control group.A statistical difference was found between the cases and the control (P ＜ 0.05,OR =2.914,95％ CI =1.41-6.01).Conclusion The polymorphism of CYP3A4 * 1 G/* 1G remained a significant independent risk factor for CNIs drug-induced chronic nephrotoxicity after kidney allograft.
