Clinical trial of levocarnitine injection combined with atorvastatin calcium tablets in the treatment of chronic heart failure
10.13699/j.cnki.1001-6821.2017.05.003
- VernacularTitle:左卡尼汀注射液联合阿托伐他汀钙片治疗慢性心力衰竭的临床研究
- Author:
Hong-Feng SHEN
1
;
Hai-Jiang XIA
Author Information
1. 绍兴市立医院老年二科
- Keywords:
levocarnitine injection;
atorvastatin calcium tablet;
chronic heart failure;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(5):395-397,407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of levocarnitine injection combined with atorvastatin calcium tablets in the treatment of chronic heart failure.Methods A total of 72 patients with chronic heart failure were randomly divided into control group and treatment group with 36 cases per group.Control group was treated with atorvastatin calcium 10 mg qd oral.Treatment group was given levocamitine injection 20 mg· kg-1 qd by intravenous injection,on the basis of the control group.Two groups were treated for 2 cycles with 21 d per cycle.The clinical efficacy,nuclear transcription factor kappa B (NF-κB),interleukin 1 β (IL-1β),C reactive protein (CRP),plasma brain natriuretic peptide (BNP),left ventricular diameter (LVID),left ventricular ejection fraction (LVEF),the maximum distance of 6 min walking test (6-MWT),and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 83.33％ (30/36 cases) and 61.11％ (22/36 cases),with significant difference (P ＜0.05).After treatment,the main indexes in treatment and control groups were compared:NF-κB were (34.44 ± 3.50),(49.57-±5.17)pg· L-1;IL-1β5 were (0.42±0.05),(0.59 ±0.07)μg· L-1;CRPwere (10.04±1.11),(13.29 ± 1.44) ng · L-1;BNP were (241.63 ± 25.77),(340.92 ± 35.16) pg · L-1;LVID were (49.19 ± 5.12),(52.11 ±5.44)mm;LVEF were (49.39 ±5.12)％,(41.02 ±4.15)％;6-MWT were (376.09 ±40.15),(262.98 ± 28.71)m,with statistically significant difference (P ＜ 0.05).The adverse drug reactions in treatment group were gastrointestinal discomfort and dry,which in control group were gastrointestinal discomfort,blurred vision and rash.The incidence of treatment and control groups were 5.56％ and 11.11％ without significant difference (P ＞0.05).Conclusion Levocarnitine injection combine with atorvastatin calcium tablets has a definitive clinical efficacy in the treatment of chronic heart failure,without increasing the incidence of adverse drug reactions.
