Clinical trial of alteplase injection in the treatment of acute ischemic stroke
10.13699/j.cnki.1001-6821.2017.05.002
- VernacularTitle:阿替普酶注射剂治疗急性缺血性脑卒中的临床研究
- Author:
Zi-Ran WANG
1
;
Mei ZHENG
;
Guang-Jian ZHAO
;
Dai-Qun YANG
;
Hong-Yan LEI
Author Information
1. 临沂市人民医院急诊科
- Keywords:
alteplase injection;
acute ischemic stroke;
thrombolysis;
aspirin
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(5):391-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of alteplase withdifferent doses and thrombolysis time in the treatment of acute ischemic stroke.Methods A total of 220 patients with acute ischemic stroke were randomly divided into A group(n =90 cases),B group(n =90 cases) and C group (n =40 cases).A group was given 0.6 mg· kg-1 alteplase,the thrombolysis timewas less than 30 minutes;B group wasgiyen 0.6 mg · kg-1 alteplase,the thrombolysis time was about 60 min;C group was given 0.9 mg · kg-1 alteplase,the thrombolysis time was about 60 min.1 d after thrombolysis treatment,all patients were given oral aspirin 100 mg qd for 3 months.The national institutes of health stroke scale (NIHSS) score and adverse drug reactions were compared between three groups.Resnlts 1 h after treatment,the NIHSS in A,B,C groups were (7.11 ±0.83),(8.24 ±0.96),(8.32 ± 1.38) points;1 d after treatment,the NIHSS in A,B,C groups were (7.92 ± 0.93),(8.92 ± 1.03),(9.09 ± 1.17) points;7 d after treatment,the NIHSS in A,B,C groups were (6.63 ± 0.77),(7.31 ± 0.83),(7.36 ± 0.88) points;30 d after treatment,the NIHSS in A,B,C groups were (4.89 ± 0.62),(5.62 ± 0.76),(5.78 ± 0.87) points;90 d after treatment,the NIHSS in A,B,C groups were (3.53 ± 0.58),(4.77 ± 0.55),(4.69 ± 0.61) points.90 d after treatment,the modified rankin scale scores in A,B,C groups were 72.22％ (65/90 cases),54.44％ (49/90 cases),55.00％ (22/40 eases).The differences were statistically significant between A group and B,C groups (P ＜ 0.05),which was not signi-ficant between B group and C group (P ＞ 0.05).The adverse drug reactions were based on gingival bleeding,the incidences of adverse drug reactions in A,B,C groups were 8.89％,12.22％,17.50％ without significant difference (P ＞ 0.05).ConclusionAlteplasehasa definitive clinical efficacy in the treatment of acute ischemie strokewith the dose of 0.6 mg· kg-1 and intravenous thrombolysis time ＜ 30 min,which can reduce the financial burden,without increasing the incidence of adverse drug reactions.
