Research advancement of drug interactions with ethanol
10.13699/j.cnki.1001-6821.2017.04.025
- VernacularTitle:乙醇与药物相互作用的研究现状
- Author:
Nan ZHANG
1
;
Xia ZHAO
;
Ying ZHOU
;
Yi-Min CUI
Author Information
1. 北京大学第一医院药剂科
- Keywords:
drug;
ethanol;
pharmacokinetics;
pharmacodynamics;
interaction
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(4):381-384
- CountryChina
- Language:Chinese
-
Abstract:
Ethanol is metabolized by alcohol dehydrogenase (ADH) and cytochrome P450 2E1 (CYP2E1) metabolizing enzymes,and drugs that affect or metabolize enzymes metabolised by ADH and CYP2E1 are likely to interact with ethanol.The effect of ethanol on the drugs may produce pharmacokinetic or pharmacodynamic changes.We will review the interaction mechanism of various drugs with ethanol.
