Analysis the factors of influencing on the concentrations of clopidogrel active metabolite in plasma of patients with acute coronary syndrome
10.13699/j.cnki.1001-6821.2017.04.018
- VernacularTitle:分析急性冠状动脉综合征患者体内氯吡格雷活性代谢产物的影响因素
- Author:
Zi-Yun SU
1
;
Ye YUAN
;
Wan-Yan CHEN
;
Hao-Ran LI
;
Yi PENG
;
Jian LIU
;
Xiu-Ling YANG
Author Information
1. 河北医科大学第二医院药学部
- Keywords:
acute coronary syndrome;
clopidogrel;
active metabolite;
blood drug concentration
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(4):355-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the factors influencing the concentrations of clopidogrel active metabolite in plasma of patients with acute coronary syndrome(ACS).Methods One hundred and five patients with ACS were administrated aspirin (100 mg · d-1) and clopidogrel (75 mg · d-1) for 4 days.On day 5,blood samples (approximate 4 mL) were collected at 1 h after administration with empty stomach.Half of the blood added 20 μL 2-Bromo-3'-methoxyacetophenone (MPB,500 mmol · L-1) immediately was used for the determination of clopidogrel active metabolite.And the other was used for detecting the cytochrome P450 2C19 * 2 (CYP2C19 * 2),* 3,and paraoxonase-1 (PON1).By using single factor analysis,the binary variable and ranked data related to the blood drug concentration of clopidogrel active metabolites were analyzed.And the measurement data related to the blood drug concentration of clopidogrel active metabolites were analyzed using Spearman analysis.Results The concentration of clopidogrel active metabolites had a significantly negative correlation with diabetes,hyperlipidemia,percutaneous coronary intervention (PCI),PON1 carrier (P ＜ 0.05);but positive correlation with β-blockers,statins and serum albumin(ALB) (P ＜ 0.05).Conclusion The diabetes,hyperlipidemia,PCI can reduce the concentration of clopidogrel active metabolites in blood;while the ALB,β-blockers and statins can increase the concentration of clopidogrel active metabolites in blood.
