Effect of atorvastatin preconditioning on cerebral myelin basic protein, glial fibrillary acidic protein and neurospecific enolase in cerebral ischemia reperfusion
10.13699/j.cnki.1001-6821.2017.04.011
- VernacularTitle:阿托伐他汀片对脑缺血再灌注大鼠髓鞘碱性蛋白和神经胶质纤维酸性蛋白及神经元特异性烯醇化酶的影响
- Author:
Min GAO
1
;
Lü-Li LI
;
Jun-Jie WEI
;
Xiao-Feng LI
;
Yan-Hua LI
;
Li-Xiang ZHANG
;
Bing-Lin FAN
;
Zhi CHEN
;
Hun FENG
Author Information
1. 广西壮族自治区人民医院神经内科
- Keywords:
cerebral ischemia reperfusion;
atorvastatin;
myelin basic protein;
glial fibrillary acidic protein;
neurospecific enolase
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(4):327-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of atorvastatin preconditioning on cerebral myelin basic protein (MBP),glial fibrillary acidic protein (GFAP) and neurospecific enolase (NSE) in rat model of cerebral ischemia reperfusion.Methods A total of 30 male SD rats were randomly assigned to test group,model group and sham group.The rats of test group received atorvastatin 5 mg · kg-1 · d-1 by gastric gavage for 5 consecutive days before modling while the other two groups received the same volume of 0.9％ NaC1.Right middle cerebral artery occlusion (MCAO) ischemia-reperfusion model was established in both model group and test group,while sham group was only subjected to right middle cerebral artery separation and suture.The expressions of cerebral NSE,MBP and GFAP were measured with immunohistochemistry after 24 h reperfusion.Results The expressions of NSE,MBP and GFAP were 0.11 ±0.03,0.11 ±0.02,0.14 ±0.04 in model group,had significant differences with those in sham group,which were 0.18±0.02,0.11 ±0.00,0.19 ± 0.02 (P ＜ 0.05).The expressions of NSE and MBP in test group were 0.14 ± 0.02,0.14 ± 0.02,had significant differences with those of model group (P ＜0.05).The expression of GFAP in test group had no statistical significance with model group (P ＞ 0.05).Conclusion Atorvastatin preconditioning can alleviate cerebral ischemia reperfusion injury in rats with MCAO,probably through protecting oligodendrocytes and neurons.
