Clinical trial of magnesium isoglycyrrhizinate in the treatment of patients with benign obstructive jaundice
10.13699/j.cnki.1001-6821.2017.04.004
- VernacularTitle:异甘草酸镁治疗良性梗阻性黄疸患者的临床研究
- Author:
Wen-Yuan SONG
1
;
Lei WU
;
Hong-Yan ZHAO
;
Xue-Guo WANG
;
Huai-Wen WANG
;
Ning WU
Author Information
1. 海南省农垦总医院肝胆胰外科
- Keywords:
benign obstructive jaundice;
percutaneous liver puncture and biliary drainage;
magnesium isoglycyrrhizinate;
reduced glutathione
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(4):301-303,307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of magnesium isoglycyrrhizinate(MIG) in the treatment of patients with benign obstructive jaundice(BOJ).Methods Eighty cases of BOJ in our hospital from June 2013 to October 2015 were selected and randomly divided into the control group and the treatment group,40 cases in each group.The treatment group was given intravenous injection of 100 mg · d-1 MIG and the control group was injected with reduced glutathione 1200 mg· d-1,and the course of treatment was 8 days.After the 8 days treatment,the alanine aminotransferase (ALT) and aspartate aminotransferase (AST),albumin (ALB),γ-glutamyl transferase (GGT),skin alkaline phosphatase (ALP),total bilirubin (TBIL),direct bilirubin (DBIL),tumor necrosis factor (TNF-α) and nuclear factor (NF) level were determined by biochemical analyzer.The drug adverse reactions were observed.Results After treatment of 8 days,the treatment group and control group:ALTwere (59.9±24.7),(92.4±37.1) U· L-1 respectively;ASTwere (69.1 ±36.5),(84.7±45.2)U · L-1 respectively;ALP were (140.7 ± 37.8),(192.7 ±45.2) U · L-1 respectively;TBIL were (70.1 ±14.9),(98.8 ±24.8) mol,L-1respectively;DBILwere (50.3 ±6.4),(76.6±15.4) mol· L-1 respectively,compared with those before treatment,the differences were statistically significant (all P ＜ 0.05).Compared with the control group,the ALP,ALT,AST,TBIL and DBIL significantly decreased (all P ＜ 0.05).The improvement of ALB and GGT was not obvious significance,and there was no significant difference between the two groups before and after treatment as well as between the two groups (all P ＞ 0.05).At the same time,after treatment of 8 days,the treatment group and control group:TNF-α were (21.6 ± 9.2),(32.5 ± 7.8) g · mL-1 respectively;NF were (14.3 ± 7.3),(22.7 ± 11.8) pg · mL-1 respectively.They significantly decreased compared with those before treatment (all P ＜ 0.05).Conclusion MIG can prevent the progression and deterioration of the disease after percutaneous liver puncture and biliary drainage,reduce the complications,and improve the prognosis.
