Clinical trial of piperacillin sodium and tazobactam sodium for injection combined with dexamethasone injection in the treatment of community acquired pneumonia with fever
10.13699/j.cnki.1001-6821.2017.04.001
- VernacularTitle:哌拉西林钠他唑巴坦钠注射剂联合地塞米松注射液治疗社区获得性肺炎伴发热的临床研究
- Author:
Bin WU
1
;
Rong-Juan ZHAO
Author Information
1. 浙江萧山医院呼吸内科
- Keywords:
piperacillin sodium and tazobactam sodium for injection;
dexamethasone;
community acquired pneumonia;
fever;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(4):291-293,300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of piperacillin sodium and tazobactam sodium for injection combined with dexamethasone in the treatment of community acquired pneumonia with fever.Methods Fifty-six patients with community acquired pneumonia with fever were randomly divided into control group (n =28 cases) and treatment group (n =28 cases).Control group was given intravenous infusion of piperacillin sodium and tazobactam sodium for injection 4.5 g bid.Treatment group was treated with intravenous infusion of dexamethasone 5 mg qd with continuous use for 3 d,on the basis of the control group.Two groups were treated for 10 d.The clinical efficacy,serum tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),IL-10 and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 96.43％ (27/28 cases) and 78.57％ (22/28 cases) with significant difference (P ＜0.05).After treatment,the main indexes in treatment and control groups were compared:the temperature were (37.35 ± 1.63),(38.42 ± 1.72)℃C;TNF-α were (90.56 ± 12.76),(125.25 ±16.45) pg · mL-1;IL-6 were (42.56 ± 3.22),(74.79 ± 4.73) pg · mL-1;IL-10 were (19.76 ± 0.35),(36.35 ± 1.64) pg · mL-1,the differences were significant (P ＜ 0.05).The drug adverse reactions in treatment group were based on mainly nausea,diarrhea and dizziness,which in the control group were based on diarrhea,dizziness and injection site pain.The incidences of adverse drug reactions in treatment and control groups were 14.29％ and 10.71％ without significant difference (P ＞0.05).Conclusion Piperacillin sodium and tazobactam sodium for injection combined with dexamethasone has a definitive clinical efficacy in the treatment of community acquired pneumonia with fever,which can reduce the inflammatory response,without increasing the incidence of adverse drug reactions.
