Clinical trial of ribavirin injection combined with qingkailing injection in the treatment of children with virus pneumonia
10.13699/j.cnki.1001-6821.2017.03.020
- VernacularTitle:利巴韦林注射液联合清开灵注射液治疗小儿病毒性肺炎的临床研究
- Author:
Ji-Hong LI
1
;
Yan DENG
;
De-Lian LAN
;
Ze WANG
;
Yong-Qiang WANG
Author Information
1. 内江市第二人民医院儿科
- Keywords:
ribavirin injection;
qingkailing injection;
children viral pneumonia;
pulmonary function;
inflammatory reaction
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(3):262-264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of ribavirin injection combined with qingkailing injection in the treatment of children virus pneumonia.Methods A total of 105 children with viral pneumonia were randomly divided into control group (n =52 cases) and treatment group (n =53 cases).Control group was given intravenous infusion of ribavirin injection 10 mg · kg-1 · d-1 qd.Treatment group was treated with intravenous infusion of qingkailing injection,which was given 6 mL qd for 1-2 years children and 10 mL qd for 3-6 years children,on the basis of control group.Two groups were treated for 7 d.The clinical efficacy,levels of inflammatory cytokine,lung function indexes,disappearance time of symptoms and signs,and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 92.45％ (49/53cases) and 73.08％ (38/52 cases)with significance difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:interleukin-6 were (23.13 ± 5.12),(42.91 ± 6.81) ng · L-1;interleukin-8 were (9.10 ± 2.13),(15.03 ± 3.51) ng · L-1;tumor necrosis factor-α were (27.12 ± 4.67),(38.97-9.09)ng · L-1;per kilogram of tidal volume were (7.93--1.29),(6.73 ± 1.20)mL · kg-1;peak expiratory time / expiratory time were (45.13 ± 6.78) ％,(32.16 ± 5.71) ％;respiratory rates were (23.51 ± 4.59),(27.98 ±4.12) beat · min-1;fever clearance time were (2.19 ±0.61),(4.21 ± 1.30) d;disappearance time of cough were (4.31 ± 1.27),(5.98 ± 1.43) d;disappearance time of pulmonary rales were (3.41 ± 1.04),(5.59 ± 1.43)d,the differences were statistically significant (P ＜ 0.05).There were no adverse drug reactions occurred during the treatment.Conclusion Qingkailing injection combined with ribavirin injection has a definitive clinical efficacy and safety in the treatment of children virus pneumonia,which can improve the lung function obviously and reduce the inflammatory reactions.
