Clinical Manifestations and Genotypes of Human Papillomavirus in Korean Patients with Condyloma Acuminatum.
- Author:
Hyun Seok CHOI
1
;
Hyun Min SEO
;
Joung Soo KIM
;
Hee Joon YU
Author Information
1. Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea. yuhjoon@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Condyloma acuminatum;
Human papillomavirus
- MeSH:
Clinical Study;
Coinfection;
Diagnosis;
Female;
Genotype*;
Humans*;
Korea;
Male;
Recurrence;
Sexually Transmitted Diseases
- From:Korean Journal of Dermatology
2017;55(7):394-400
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Condyloma acuminatum is a sexually transmitted disease (STD) associated with the human papillomavirus (HPV). Although it is a relatively common disease, there has been no epidemiological and clinical study of condyloma acuminatum performed in Korea since 1978. OBJECTIVE: We aimed to evaluate the clinical features of condyloma acuminatum in Korean patients, to identify the genotypes of HPV, as well as determine factors associated with recurrence of condyloma acuminatum. METHODS: We studied 80 patients (60 men and 20 women) diagnosed with condyloma acuminatum. We analyzed age, sex, duration of the disease, number and locations of lesions, underlying diseases and co-infection with STDs, treatment modalities, and number of relapses. Additionally, 26 patients were analyzed for HPV subtypes. We also evaluated factors affecting recurrence of condyloma. RESULTS: Mean age at the time of diagnosis was 36.9±17.7 years and mean duration of disease was 7.2±16.5 months. The most common sites of involvement were found to be the penile shaft in men and the labia majora in women. We observed that 28 patients showed relapse with a mean duration of 1.5±4.5 months. HPV genotyping revealed that type 6, 11, and 44 genotypes that are associated with a low risk of malignancy were detected in 76.9% of cases, and type 16, 18, 51, 52, and 66 genotypes associated with a high risk of malignancy were detected in 15.3% cases. A significant relationship was observed between the recurrence rates of condyloma acuminatum and the rates of co-infection with STDs and the number of lesions. CONCLUSION: We report a recent epidemiological and clinical review analyzing genotypes of HPV in Korean patients presenting with condyloma acuminatum.
