Clinical trial of edaravone injection on patients with early cerebral ischemia after clipping of intracranial aneurysm
10.13699/j.cnki.1001-6821.2017.03.002
- VernacularTitle:依达拉奉注射液治疗颅内动脉瘤夹闭术后早期脑缺血患者的临床研究
- Author:
Chi-Wen HUANG
1
;
Jin-Qing HUANG
;
Bai-Lin ZHANG
Author Information
1. 赣州市人民医院 神经外科
- Keywords:
edaravone injection;
clipping of intracranial aneurysm;
cerebral ischemia;
prognosis
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(3):199-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect of edaravone injection on patients with early cerebral ischemia (ECI) after clipping of intracranial aneurysm.Methods Seventy-eight patients with intracranial aneurysms were randomly divided into control group and treatment group,with 39 cases in each group.Patients in two groups were given the treatments of high blood volume,high perfusion pressure,blood dilution and others.On the basis of control group,treatment group was intravenously dripped edaravone 30 g mixed in 0.9％ NaCl 100 mL,finished within 30 min.Control group was intravenously dripped 0.9％ NaCl 100 mL.The treatment was lasted for 14 d.The neurological function recovery and prognosis of two groups were compared.Results After treatment,the neurologic function defect (NFD) scores in treatment and control groups were (7.36 ± 5.42),(10.71 ± 4.39) points (P ＜ 0.05).Barthel scores in treatment and control groups were (49.20 ± 13.32),(37.58 ± 11.46) points (P ＜0.05).The blood flow velocity in brain and incidence of cerebral vasospasm (CVS) in treatment group were (95.38 ± 19.60)cm · s-1,12.82％ (5/39 cases).In control group,blood flow velocity in brain and incidence of CVS were (118.25 ± 17.94)cm · s-1,33.33％ (13/39 cases).There was significant difference between the two groups (P ＜ 0.05).The Glasgow outcome score (GOS) of 5 points in treatment group was 79.49％ (31/39 cases),had significant difference with that in control group,which was 58.97％ (23/39 cases,P ＜ 0.05).Serum super oxide dismutase (SOD),nitric oxide (NO) and malonaldehyde (MDA) in treatment group were (93.26 ± 13.71) U · mL-1,(5.29 ±0.53) nmol · mL-1 and (63.29 ± 10.58) mol · L-1 after treatment.Cerebrospinal fluid SOD,NO and MDA in treatment group were (61.34 ±4.26) U · mL-1,(4.40 ± 0.25) nmol · mL-1 and (1.83 ± 0.37) mol · L-1 after treatment.Serum SOD,NO and MDA in control group were (80.20 ± 11.59) U · mL-1,(6.74 ±0.32) nmol · mL-1 and (50.91 ±9.37) mol · L-1 after treatment.Cerebrospinal fluid SOD,NO and MDA in control group were (54.29 ± 6.64) U · mL-1,(5.12 ± 0.83) nmol · mL-1 and (1.50 ± 0.24) mol · L-1 after treatment.There was significant difference between the two groups (P ＜ 0.05).There were no obvious adverse drug reactions in two groups.Conclusion The scavenging effect of edaravone on oxygen free radical in serum and cerebrospinal fluid could significantly reduce cerebral artery blood flow and CVS incidence in patients with ECI after clipping of intracranial aneurysm.
