Experimental study of allopurinol on insulin resistance in high-fructose rats
10.13699/j.cnki.1001-6821.2016.14.018
- VernacularTitle:别嘌呤醇改善高果糖诱导的大鼠胰岛素抵抗的实验研究
- Author:
Qing-Hua YANG
1
;
Yue-Hua ZOU
;
Xue-Ling YUE
;
Ling CHEN
;
Ying-Shun LI
;
Qing-Hua JIN
;
Hai-Ying JIANG
Author Information
1. 中国人民解放军65334部队医院
- Keywords:
allopurinol;
high -fructose;
insulin sensitivity index;
euglycemic clamp
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(14):1311-1313
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate allopurinol ( a xanthine oxidase in-hibitor) improves insulin resistance of rats fed with high -fructose diet. Methods Male Wistar rats were randomly divided into 3 groups and each group was fed one of the following diets for 4 weeks:standard chow diet(normal group), high -fructose diet(model group), and high -fructose diet plus allopurinol(allopurinol 25μg? g-1, test group).Insu-lin sensitivity index was assessed from the oral glucose tolerance test ( OGTT) and the euglycemic clamp studies .Results Serum uric acid and plasma insulin concentrations were significantly decreased with allo-purinol treatment.That the serum uric acid of the model group with (1.82 ±0.10 ) mg? dL-1 was significantly increased than normal group with ( 1.33 ±0.12 ) mg? dL-1 , and improved by test group with (0.90 ±0.27) mg? dL-1.There was no difference in the levels of glu-cose with OGTT among the 3 groups.The model group produced a marked decrease in insulin sensitivity index ( GIR) compared with normal group (P<0.05).Allopurinol treated high -fructose fed rats showed a signifi-cant increase in GIR , reaching a similar level as that of the normal group (P<0.05).Conclusion Allopurinol may improve of insulin resistance in high-fructose induced insulin resistant .
