Clinical trial of effect of mouse nerve growth factor combined gangliosides in the treatment of neurological function after brain injury in infant
10.13699/j.cnki.1001-6821.2016.14.005
- VernacularTitle:鼠神经生长因子联合神经节苷酯对婴儿脑损伤后神经功能修复影响的临床研究
- Author:
Yu-Ling YANG
1
;
Dong-Mei MU
;
Ling-Yan GAO
;
Zhi-Hui WANG
;
Jian LIN
Author Information
1. 温州医科大学 附属第二医院 神经外科
- Keywords:
nerve growth factor;
gangliosides;
infant;
brain injury;
neurological function;
intelligence
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(14):1265-1267
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of different dosage of mouse nerve growth factor on nerve function recovery after brain injury in infant.Methods Ninety patients with brain injury were divided into treatment group and control group , each group 45 cases.Treatment group was treated with intravenous injection of the nerve growth factor 30 μg along with gangliosides , and control group treated with nerve growth factor 18μg along with gangliosides .The clinical symptoms , neurological function score and intelligence level were compared between the two groups.Results After 7, 14 d treatment, the neurological function scores of treatment group were ( 33.80 ±1.80 ) , ( 38.20 ±1.90 ) , had no significance with ( 32.20 ±2.40 ) , ( 37.40 ±2.10 ) in control group ( P>0.05 ) .Total efficacy in treatment group was 95.56%( 43/45 ) , had no significance with 91.11%( 41/45 ) in control group ( P>0.05 ) . The intelligence level and the improvement of clinical symptoms of brain injury in treatment group had no significance with control group after treatment ( P >0.05 ) . The adverse reactions mainly manifested as nausea , vomiting and restlessness , the incidence of adverse reactions had no significant difference in two groups ( P >0.05 ) .Conclusion The low dosage mouse nerve growth factor combined gangliosides is also beneficial to the recovery of neurological function af -ter brain injury in infant.
