Clinical trial on the treatment of combined Danshen Chuanxiongqin and atorvastatin in coronary heart disease with renal injury
10.13699/j.cnki.1001-6821.2016.14.001
- VernacularTitle:丹参川芎嗪联合阿托伐他汀治疗冠心病合并肾损伤的临床研究
- Author:
Ni WANG
1
;
Wei LIU
;
Si-Rui BI
;
Ming QI
Author Information
1. 延安大学附属医院干部病房
- Keywords:
Danshen Chuanxiongqin injection;
atorvastatin;
coronary heart disease with renal injury;
retinol binding protein 4;
vascular endothelial growth factor;
myocyte enhancer factor 2 A
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(14):1251-1253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects on correlated biochemical indexes of combined Danshen Chuanxiongqin injection and atorvastatin in coronary heart disease with renal injury .Methods One hundred and fifty-four patients of coronary heart disease with renal injury were randomly divided into A ( n=51 ) , B ( n=52 ) and C ( n=51 ) group. Group A was given atorvastatin 20 mg? d-1 orally.Group B was given Danshen Chuanxiongqin injection 10 mL? d -1 intravenous infusion . Group C was given atorvastatin 20 mg? d-1 orally and Danshen Chuan-xiongqin injection 10 mL? d-1 .All patients were treated for 14 d.Levels of vascular endothelial growth factor ( VEGF ) , myocyte enhancer factor 2A(MEF2A), retinol binding protein 4(RBP4), serum creatinine(Scr) and blood urea nitrogen ( BUN ) in serum were detected before and after treatment in three groups.Results After treatment, the levels of VEGF and MEF2A in group C were (35.19 ±5.26), (12.39 ±2.12)μg? mL-1, higher than (27.37 ±3.85),(9.74 ± 1.24)μg? mL-1 in group A and(25.19 ±4.41),(8.48 ±1.18) in group B(P<0.05).The levels of RBP4, BUN and Scr of patients in group C were (53.72 ±8.26), (73.69 ±16.12), (5.39 ±1.62)mmol? L-1, had significantly difference with (78.73 ±8.85 ) ,( 89.49 ±19.83 ) , ( 7.14 ±2.24 ) mmol? L-1 in group A and ( 68.91 ±9.14 ) , (81.48 ±18.18),(6.48 ±2.18)mmol? L-1 in group B (P<0.05).The main symptoms of adverse drug reactions were chest tightness and chest pain, with no significant difference in three groups (P>0.05).Conclusion Both treat-ments can reduce blood lipid , and improve vascular endothelial function .Meanwhile , Danshen Chuanxiongqin injection play a good role on renal injury, but drug combination showed better efficacy from the change of indexes .
