Association between transforming growth factor -β1 gene T869C polymorphism and essential hypertension:A Meta-analysis

VernacularTitle:中国人群转化生长因子－β1基因 T869 C 多态性与原发性高血压相关性的 Meta分析
Author: Jie-Gen YU ¹ ; Rong LI ; Wei-Wei CHANG ; Meng-Sha TANG ; Yue-Long JIN ; Ying-Shui YAO
Author Information

1. 皖南医学院人文与管理学院
Keywords: transforming growth factor -β1; polymorphism; essential hypertension; Meta-analysis
From: The Chinese Journal of Clinical Pharmacology 2016;32(13):1231-1233
CountryChina
Language:Chinese
Abstract: Objective To evaluate the relationship between transforming growth factor-β1(TGF-β1) T869C polymorphism and essential hyper-tension (EH) using Meta-analysis, and to provide a basis for evidence-based medicine of the genetic background of EH .Methods Eligible articles published before October 2015 were collected the Chinese and foreign databases.Results A total of 7 studies(2822 cases) were avai-lable in this analysis , including 1560 cases in treatment group and 1322 cases in control group .The Meta -analysis results of T869 C genotype and the allele results showed significant difference ( P<0.01 ) .Conclu-sion TGF-β1 T869 C polymorphism might be associated with EH.