Clinical trial of carboprost tromethamine in the treatment of postpartum hemorrhage of pregnancy
10.13699/j.cnki.1001-6821.2016.13.009
- VernacularTitle:卡前列素氨丁三醇对妊娠产后出血的临床研究
- Author:
Jie CHEN
1
;
Chun-Bo QIU
Author Information
1. 宁波大学 医学院 附属医院 产一病区
- Keywords:
carboprost tromethamine injection;
postpartum hemorrhage;
nitric oxide synthase;
brain natriuretic peptide
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(13):1182-1184
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of carboprost tromethamine injection in the treatment of postpartum hemor-rhage of pregnancy.Methods A total of 76 cases with postpartum hem-orrhage of pregnancy were dividing into control group and treatment group with each 38 cases.After delivery, vaginal delivery patients in control group were given oxytocin injection 20 U by intramuscular injection ,ce-sarean section after delivery in control group were given oxytocin injection 20 U by intravenous drip.Vaginal delivery after delivery in treatment group were given carboprost tromethamine injection 250 μg by intramus-cular injection .Cesarean section after delivery in treatment group were given carboprost tromethamine 250 μg intravenous drip.The clinical effi-cacy , nitric oxide ( NO ) , nitric oxide synthase ( NOS ) , brain natriuretic peptide( BNP) and adverse drug reactions were compared between the two groups. Results The clinical efficacy in treatment group was 94.74%, significantly higher than 78.95%in control group ( P<0.05 ). The serum levels of NO , NOS and BNP were decreased after treatment with treatment group much lower than control group (10.53 vs 7.89%, P<0.05). The adverse drug reactions was not statistically different between the two groups ( 10.53 vs 7.89%, P >0.05 ) . Conclusion Carboprost tromethamine injection in treatment of postpartum hemorrhage of pregnancy was effective with high safety .
